Concepedia

Base Damage Recognition

Base Damage Recognition is a molecular mechanism in DNA repair that identifies and binds to chemically altered or mismatched nitrogenous bases within the genome, initiating the base excision repair pathway by distinguishing damaged bases from undamaged ones through specific enzyme-substrate interactions.

107

Publications

7.9K

Citations

442

Authors

163

Institutions

Publications per year

2017–2026

16

Parents

Publications

107

A multistep damage recognition mechanism for global genomic nucleotide excision repair

Kaoru Sugasawa, Tomoko Okamoto, Yuichiro Shimizu et al. · Genes & Development · 2001 · 428 citations · Full text

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XERODERMA PIGMENTOSUM: A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE

James E. Cleaver · Proceedings of the National Academy of Sciences · 1969 · 417 citations · Full text

, , +16

Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

Julia Tchou, Varun Bodepudi, Shinya Shibutani et al. · Journal of Biological Chemistry · 1994 · 331 citations · Full text

, , +15

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

Cecilia Ström, Fredrik Johansson, Mathias Uhlén et al. · Nucleic Acids Research · 2010 · 298 citations · Full text

, , +17

Atomic model of a pyrimidine dimer excision repair enzyme complexed with a dna substrate: Structural basis for damaged DNA recognition

Dmitry G. Vassylyev, Tatsuki Kashiwagi, Yuriko Mikami et al. · Cell · 1995 · 265 citations · Full text

, , +17

1–5 of 107

Authors

442

  1. AS
    Aziz Sancar

    University of North Carolina at Chapel Hill, United States

    6 publications · 570 citations

    6

    h-index

  2. NE
    Nicholas E. Geacintov

    New York University, United States

    4 publications · 150 citations

    4

    h-index

  3. JT
    James T. Stivers

    Johns Hopkins University, United States

    4 publications · 269 citations

    4

    h-index

  4. AP
    Arthur P. Grollman

    Stony Brook University, United States

    4 publications · 485 citations

    4

    h-index

  5. SS
    Sheila S. David

    University of California, Davis, United States

    4 publications · 148 citations

    4

    h-index

1–5 of 442

Institutions

163

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    10 h-index

    41 publications

    2.5K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    17 publications

    448 citations

  3. Stony Brook University

    Stony Brook, United States

    6 h-index

    26 publications

    3.2K citations

  4. New York University

    New York, United States

    5 h-index

    26 publications

    926 citations

  5. Institute of Chemical Biology and Fundamental Medicine

    Novosibirsk, Russia

    5 h-index

    18 publications

    892 citations

  6. Siberian Branch of the Russian Academy of Sciences

    Novosibirsk, Russia

    4 h-index

    9 publications

    496 citations

  7. Johns Hopkins University

    Baltimore, United States

    4 h-index

    14 publications

    913 citations

  8. Peking University

    Beijing, China

    3 h-index

    20 publications

    840 citations

1–8 of 163

Venues

  1. Nucleic Acids Research

    20 publications · 1.3K citations

    19

    h-index

  2. Journal of Biological Chemistry

    JBC · 13 publications · 1.3K citations

    13

    h-index

  3. Biochemistry

    10 publications · 466 citations

    10

    h-index

  4. Journal of Molecular Biology

    JMB · 7 publications · 491 citations

    7

    h-index

  5. Journal of the American Chemical Society

    JACS · 6 publications · 195 citations

    6

    h-index

1–5