Concepedia

Atr Deficiency

ATR Deficiency is a genetic disorder characterized by impaired function of the ataxia telangiectasia and Rad3-related protein kinase, leading to defective DNA damage response signaling and genomic instability.

152

Publications

12.6K

Citations

1.1K

Authors

381

Institutions

Publications per year

2017–2026

49

Parents

Publications

152

Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

Yaroslava Ruzankina, Carolina Pinzon‐Guzman, Amma Asare et al. · Cell stem cell · 2007 · 808 citations · Full text

, , +17

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

Mark O’Driscoll, Víctor L. Ruiz‐Pérez, C. Geoffrey Woods et al. · Nature Genetics · 2003 · 778 citations · Full text

, , +16

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

Richard J. Gibbons, Tarra L. McDowell, Sundhya Raman et al. · Nature Genetics · 2000 · 492 citations

, , +14

ATR couples FANCD2 monoubiquitination to the DNA-damage response

Paul R. Andreassen, Alan D. D’Andrea, Toshiyasu Taniguchi · Genes & Development · 2004 · 415 citations · Full text

, , +17

Splicing Defects in the Ataxia-Telangiectasia Gene, ATM: Underlying Mutations and Consequences

Sharon N. Teraoka, Milhan Telatar, Sara Becker-Catania et al. · The American Journal of Human Genetics · 1999 · 316 citations · Full text

, , +13

1–5 of 152

Authors

1.1K

  1. MO
    Mark O’Driscoll

    University of Sussex, United Kingdom

    8 publications · 1.5K citations

    8

    h-index

  2. PA
    Penny A. Jeggo

    University of Sussex, United Kingdom

    7 publications · 1.5K citations

    7

    h-index

  3. DR
    Douglas R. Higgs

    John Radcliffe Hospital, United Kingdom

    7 publications · 1.2K citations

    7

    h-index

  4. MM
    Matilde Murga

    Spanish National Cancer Research Centre, Spain

    6 publications · 718 citations

    6

    h-index

  5. ÓF
    Óscar Fernández-Capetillo

    Spanish National Cancer Research Centre, Spain

    6 publications · 718 citations

    6

    h-index

1–5 of 1.1K

Institutions

381

  1. Harvard University

    Cambridge, United States

    10 h-index

    50 publications

    4.9K citations

  2. University of Sussex

    Brighton, United Kingdom

    9 h-index

    27 publications

    5.4K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    8 h-index

    56 publications

    7.3K citations

  4. Johns Hopkins Medicine

    Baltimore, United States

    7 h-index

    21 publications

    1.4K citations

  5. Spanish National Cancer Research Centre

    Madrid, Spain

    7 h-index

    34 publications

    3.6K citations

  6. Johns Hopkins University

    Baltimore, United States

    7 h-index

    22 publications

    1.7K citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    6 h-index

    15 publications

    2.1K citations

  8. University of Michigan

    Ann Arbor, United States

    6 h-index

    33 publications

    6.3K citations

1–8 of 381

Venues

  1. Human Molecular Genetics

    9 publications · 587 citations

    9

    h-index

  2. Nature Communications

    7 publications · 537 citations

    7

    h-index

  3. Journal of Biological Chemistry

    JBC · 6 publications · 453 citations

    6

    h-index

  4. Cell Cycle

    6 publications · 122 citations

    6

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 434 citations

    5

    h-index

1–5