Concepedia

Atp7a Function

ATP7A Function is a molecular biology construct that denotes the specific role of the ATP7A copper-transporting ATPase in mediating intracellular copper homeostasis by facilitating copper translocation across cellular membranes, particularly from the cytosol into the trans-Golgi network and across the blood-brain barrier, thereby enabling copper-dependent enzyme activation and systemic copper distribution.

334

Publications

19.3K

Citations

1.6K

Authors

578

Institutions

Publications per year

2017–2026

94

Parents

Publications

334

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

Carine White, Jaekwon Lee, Taiho Kambe et al. · Journal of Biological Chemistry · 2009 · 520 citations · Full text

, , +14

Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.

Masanobu Komatsu, Tomoyuki Sumizawa, Masato Mutoh et al. · PubMed · 2000 · 333 citations

, , +15

Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

Wei Gao, Zhao Huang, Jiufei Duan et al. · Molecular Oncology · 2021 · 332 citations · Full text

, , +17

Neonatal Diagnosis and Treatment of Menkes Disease

Stephen G. Kaler, Courtney Holmes, David S. Goldstein et al. · New England Journal of Medicine · 2008 · 319 citations · Full text

, , +17

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Léo Aubert, Neethi Nandagopal, Zachary Steinhart et al. · Nature Communications · 2020 · 314 citations · Full text

, , +16

1–5 of 334

Authors

1.6K

  1. MJ
    Michael J. Petris

    University of Missouri, United States

    23 publications · 2.4K citations

    21

    h-index

  2. SL
    Svetlana Lutsenko

    Johns Hopkins University, United States

    22 publications · 1.3K citations

    20

    h-index

  3. JF
    Julian F. B. Mercer

    Deakin University, Australia

    21 publications · 1.4K citations

    18

    h-index

  4. SG
    Stephen G. Kaler

    National Institutes of Health, United States

    14 publications · 849 citations

    13

    h-index

  5. SL
    Sharon La Fontaine

    Deakin University, Australia

    13 publications · 962 citations

    12

    h-index

1–5 of 1.6K

Institutions

578

  1. Johns Hopkins University

    Baltimore, United States

    25 h-index

    93 publications

    5.5K citations

  2. Deakin University

    Burwood, Australia

    21 h-index

    74 publications

    5K citations

  3. University of Missouri

    Columbia, United States

    18 h-index

    78 publications

    8.2K citations

  4. Johns Hopkins Medicine

    Baltimore, United States

    18 h-index

    57 publications

    4.1K citations

  5. National Institutes of Health

    Bethesda, United States

    15 h-index

    36 publications

    2.1K citations

  6. Oregon Health & Science University

    Portland, United States

    15 h-index

    42 publications

    2.7K citations

  7. The University of Melbourne

    Melbourne, Australia

    12 h-index

    33 publications

    2.8K citations

  8. Eunice Kennedy Shriver National Institute of Child Health and Human Development

    Bethesda, United States

    12 h-index

    29 publications

    1.2K citations

1–8 of 578

Venues

  1. Journal of Biological Chemistry

    JBC · 28 publications · 2.4K citations

    26

    h-index

  2. Human Molecular Genetics

    13 publications · 1.2K citations

    13

    h-index

  3. Metallomics

    17 publications · 500 citations

    13

    h-index

  4. Biochemical Journal

    BJ · 9 publications · 403 citations

    9

    h-index

  5. PLoS ONE

    9 publications · 327 citations

    9

    h-index

1–5