Antigen Affinity Discrimination is a B cell receptor signaling mechanism that enables B cells to differentially respond to antigens based on the strength of binding affinity between the B cell receptor and its cognate antigen, thereby selecting high-affinity clones for downstream immune activation.
27
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2.2K
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145
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67
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2017–2026
11
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Publications
27
B Cell Ligand Discrimination Through a Spreading and Contraction Response
Sebastian J. Fleire, Jacki Goldman, Yolanda R. Carrasco et al. · Science · 2006 · 427 citations
B Cells Use Mechanical Energy to Discriminate Antigen Affinities
Elizabeth Natkanski, Wing-Yiu Jason Lee, Bhakti Mistry et al. · Science · 2013 · 325 citations · Full text
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Authors
145
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1–5 of 145
Institutions
67
University of Oxford
Oxford, United Kingdom
3 h-index
16 publications
599 citations
Medical Research Council
London, United Kingdom
3 h-index
12 publications
756 citations
Scripps Research Institute
San Diego, United States
3 h-index
10 publications
230 citations
National Institute of Allergy and Infectious Diseases
Bethesda, United States
2 h-index
5 publications
471 citations
University of Basel
Basel, Switzerland
2 h-index
3 publications
172 citations
John Radcliffe Hospital
Oxford, United Kingdom
2 h-index
10 publications
328 citations
University of California, Davis
Davis, United States
2 h-index
7 publications
133 citations
MRC Human Immunology Unit
Oxford, United Kingdom
2 h-index
5 publications
108 citations
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Venues
- Proceedings of the National Academy of Sciences
PNAS · 3 publications · 171 citations
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- Science
2 publications · 752 citations
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- The EMBO Journal
2 publications · 265 citations
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- Nature Communications
2 publications · 108 citations
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- The Journal of Experimental Medicine
1 publications · 139 citations
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