Concepedia

Antibody Effector Function Modulation

Antibody Effector Function Modulation is a methodological approach in glycoengineering that selectively alters the glycosylation patterns of antibodies to fine-tune their interactions with Fc receptors and complement proteins, thereby modulating downstream immune effector functions such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and phagocytosis.

117

Publications

8.4K

Citations

742

Authors

229

Institutions

Publications per year

2017–2026

36

Parents

Publications

117

Control of Recombinant Monoclonal Antibody Effector Functions by Fc <i>N</i>‐Glycan Remodeling in Vitro

Jason Hodoniczky, Yuan Zheng, David C. James · Biotechnology Progress · 2005 · 388 citations

, , +17

Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents

Mark S. Cragg, Martin J. Glennie · Blood · 2003 · 358 citations

, , +16

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

Megan Lo, Hok Seon Kim, Raymond K. Tong et al. · Journal of Biological Chemistry · 2017 · 330 citations · Full text

, , +16

Modulating IgG effector function by Fc glycan engineering

Tiezheng Li, David J. DiLillo, Stylianos Bournazos et al. · Proceedings of the National Academy of Sciences · 2017 · 328 citations · Full text

, , +17

Modulation of therapeutic antibody effector functions by glycosylation engineering: Influence of Golgi enzyme localization domain and co‐expression of heterologous β1, 4‐<i>N</i>‐acetylglucosaminyltransferase III and Golgi α‐mannosidase II

Claudia Ferrara, Peter Brünker, Tobias Suter et al. · Biotechnology and Bioengineering · 2006 · 303 citations

, , +17

1–5 of 117

Authors

742

  1. FN
    Falk Nimmerjahn

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    6 publications · 504 citations

    6

    h-index

  2. LW
    Lai‐Xi Wang

    University of Maryland, Baltimore, United States

    6 publications · 824 citations

    6

    h-index

  3. RJ
    Randall J. Brezski

    Janssen (United States), United States

    4 publications · 454 citations

    4

    h-index

  4. MP
    Matthias Peipp

    Christian-Albrechts-Universität zu Kiel, Germany

    4 publications · 296 citations

    4

    h-index

  5. TV
    Thomas Valerius

    Christian-Albrechts-Universität zu Kiel, Germany

    4 publications · 296 citations

    4

    h-index

1–5 of 742

Institutions

229

  1. Friedrich-Alexander-Universität Erlangen-Nürnberg

    Erlangen, Germany

    6 h-index

    14 publications

    1K citations

  2. Kyowa Kirin (Japan)

    Tokyo, Japan

    5 h-index

    11 publications

    998 citations

  3. University of Maryland, College Park

    College Park, United States

    5 h-index

    18 publications

    1.8K citations

  4. University of Oxford

    Oxford, United Kingdom

    4 h-index

    14 publications

    1.5K citations

  5. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    4 h-index

    39 publications

    2.2K citations

  6. Southampton General Hospital

    Southampton, United Kingdom

    3 h-index

    12 publications

    881 citations

  7. Genmab (Netherlands)

    Utrecht, Netherlands

    3 h-index

    14 publications

    1.7K citations

  8. Netherlands Metabolomics Centre

    Utrecht, The Netherlands

    3 h-index

    9 publications

    471 citations

1–8 of 229

Venues

  1. mAbs

    8 publications · 381 citations

    8

    h-index

  2. PubMed

    Repository · 7 publications · 367 citations

    7

    h-index

  3. Frontiers in Immunology

    7 publications · 455 citations

    7

    h-index

  4. The Journal of Immunology

    JI · 6 publications · 384 citations

    6

    h-index

  5. Blood

    6 publications · 892 citations

    6

    h-index

1–5