Concepedia

Alternative End Joining

Alternative End Joining is a DNA repair pathway that functions as a backup mechanism to classical non-homologous end joining, characterized by its reliance on microhomology-mediated end alignment and distinct enzymatic factors for the ligation of double-strand breaks.

112

Publications

10.2K

Citations

638

Authors

231

Institutions

Publications per year

2017–2026

51

Variants

Alt-ejMicrohomology-mediated End JoiningMmej

Parents

Publications

112

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

Nicole Bennardo, Anita Cheng, Nick Huang et al. · PLoS Genetics · 2008 · 863 citations · Full text

, , +16

Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining

Marc Audebert, Bernard Salles, Patrick Calsou · Journal of Biological Chemistry · 2004 · 683 citations · Full text

, , +17

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

Anyong Xie, Amy Kwok, Ralph Scully · Nature Structural & Molecular Biology · 2009 · 340 citations · Full text

, , +9

Rag mutations reveal robust alternative end joining

Barbara Corneo, Rebecca Wendland, Ludovic Deriano et al. · Nature · 2007 · 316 citations

, , +10

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

Deniz Simsek, Maria Jasin · Nature Structural & Molecular Biology · 2010 · 312 citations · Full text

, , +13

1–5 of 112

Authors

638

  1. GI
    George Iliakis

    University of Duisburg-Essen, Germany

    8 publications · 378 citations

    9

    h-index

  2. FW
    Frederick W. Alt

    Howard Hughes Medical Institute, United States

    7 publications · 639 citations

    7

    h-index

  3. EM
    Emil Mladenov

    University of Duisburg-Essen, Germany

    5 publications · 195 citations

    6

    h-index

  4. BS
    Bernard S. López

    Centre National de la Recherche Scientifique, France

    5 publications · 314 citations

    5

    h-index

  5. MM
    Mitch McVey

    Tufts University, United States

    5 publications · 554 citations

    5

    h-index

1–5 of 638

Institutions

231

  1. Harvard University

    Cambridge, United States

    13 h-index

    52 publications

    5.5K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    56 publications

    6.5K citations

  3. Inserm

    Paris, France

    10 h-index

    42 publications

    3.8K citations

  4. University of Duisburg-Essen

    Essen, Germany

    8 h-index

    30 publications

    1.4K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    37 publications

    5.8K citations

  6. Memorial Sloan Kettering Cancer Center

    New York, United States

    7 h-index

    27 publications

    3K citations

  7. Rockefeller University

    New York, United States

    6 h-index

    19 publications

    2.9K citations

  8. University of Toronto

    Toronto, Canada

    5 h-index

    27 publications

    1K citations

1–8 of 231

Venues

  1. Nucleic Acids Research

    19 publications · 1.1K citations

    18

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 895 citations

    14

    h-index

  3. Nature Communications

    7 publications · 506 citations

    7

    h-index

  4. PLoS Genetics

    6 publications · 1.7K citations

    6

    h-index

  5. Nature Structural & Molecular Biology

    6 publications · 1.3K citations

    6

    h-index

1–5