Concepedia

Alpha-hydroxylation Coupling

Alpha-Hydroxylation Coupling is a biochemical reaction mechanism in which the alpha-hydroxylation of a peptide precursor is enzymatically linked to the subsequent amidation of its C-terminal glycine residue, thereby enabling the maturation of bioactive peptides through coordinated oxidative and amidating steps.

66

Publications

1.9K

Citations

269

Authors

88

Institutions

Publications per year

2017–2026

7

Parents

Publications

66

Sir2 Protein Deacetylases:  Evidence for Chemical Intermediates and Functions of a Conserved Histidine

Brian C. Smith, John M. Denu · Biochemistry · 2005 · 102 citations · Full text

, , +12

Reversal of regioselection in the asymmetric aminohydroxylation of cinnamates

Beata Tao, Gunther Schlingloff, K. Barry Sharpless · Tetrahedron Letters · 1998 · 102 citations

, , +7

New entry to syn-β-hydroxy-α-amino acids

Mosahiro Hirama, Hideaki Hioki, Shô Itô · Tetrahedron Letters · 1988 · 83 citations

, , +10

A facile cleavage of oxirane with hydrazoic acid in dmf A new route to chiral β-hydroxy-α-amino acids

Seiki Saitô, Norio Bunya, Masami Inaba et al. · Tetrahedron Letters · 1985 · 73 citations

, , +12

Truncated diastereoselective Passerini reaction, a rapid construction of polysubstituted oxazole and peptides having an α-hydroxy-β-amino acid component

Guylaine Cuny, Rocío Gámez‐Montaño, Jieping Zhu · Tetrahedron · 2004 · 56 citations · Full text

, , +14

1–5 of 66

Authors

269

  1. TM
    Toshio Moriwake

    Okayama University, Japan

    2 publications · 120 citations

    2

    h-index

  2. DJ
    Douglas J. Pettibone

    United States Military Academy, United States

    2 publications · 52 citations

    2

    h-index

  3. HC
    H. C. J. OTTENHEIJM

    Radboud University Nijmegen, Netherlands

    2 publications · 44 citations

    2

    h-index

  4. MG
    Mark G. Bock

    United States Military Academy, United States

    2 publications · 52 citations

    2

    h-index

  5. CT
    Cuyue Tang

    United States Military Academy, United States

    2 publications · 52 citations

    2

    h-index

1–5 of 269

Institutions

88

  1. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    17 publications

    642 citations

  2. National Chemical Laboratory

    Pune, India

    3 h-index

    9 publications

    300 citations

  3. United States Military Academy

    West Point, United States

    2 h-index

    40 publications

    1.1K citations

  4. Radboud University Nijmegen

    Nijmegen, The Netherlands

    2 h-index

    7 publications

    181 citations

  5. Institut de Chimie des Substances Naturelles

    Gif-sur-Yvette, France

    2 h-index

    6 publications

    309 citations

  6. Henan Medical University

    Xinxiang, China

    2 h-index

    13 publications

    174 citations

  7. Université de Lorraine

    Nancy, France

    2 h-index

    8 publications

    228 citations

  8. Okayama University

    Okayama, Japan

    2 h-index

    9 publications

    553 citations

1–8 of 88

Venues

  1. Tetrahedron Letters

    20 publications · 757 citations

    17

    h-index

  2. Tetrahedron

    15 publications · 374 citations

    13

    h-index

  3. Tetrahedron Asymmetry

    4 publications · 93 citations

    4

    h-index

  4. The Journal of Organic Chemistry

    JOC · 4 publications · 149 citations

    4

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    3 publications · 67 citations

    3

    h-index

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