Concepedia

Alpha-helix Mimics

Alpha-Helix Mimics is a peptidomimetic construct designed to structurally and functionally emulate the secondary conformation of an alpha-helix by stabilizing the spatial orientation of key side-chain residues through non-peptidic scaffolds, thereby preserving protein-protein interaction interfaces while enhancing metabolic stability and bioavailability.

235

Publications

13.5K

Citations

1K

Authors

315

Institutions

Publications per year

2017–2026

31

Variants

Alpha-helix Mimetics

Parents

Publications

235

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert et al. · Journal of Medicinal Chemistry · 2005 · 427 citations · Full text

, , +14

Toward Proteomimetics:  Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix

Brendan P. Orner, Justin T. Ernst, Andrew D. Hamilton · Journal of the American Chemical Society · 2001 · 313 citations

, , +12

Miniantibodies: use of amphipathic helixes to produce functional, flexibly linked dimeric FV fragments with high avidity in Escherichia coli

Peter Pack, A. Plueckthun · Biochemistry · 1992 · 293 citations

, , +13

Design and Application of an α‐Helix‐Mimetic Scaffold Based on an Oligoamide‐Foldamer Strategy: Antagonism of the Bak BH3/Bcl‐xL Complex

Justin T. Ernst, Jorge Becerril, Hyung Soon Park et al. · Angewandte Chemie International Edition · 2003 · 264 citations · Full text

, , +15

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

Hyunil Jo, Nataline Meinhardt, Yibing Wu et al. · Journal of the American Chemical Society · 2012 · 255 citations · Full text

, , +16

1–5 of 235

Authors

1K

  1. AD
    Andrew D. Hamilton

    Yale University, United States

    22 publications · 1.8K citations

    17

    h-index

  2. AJ
    Andrew J. Wilson

    University of Leeds, United Kingdom

    14 publications · 658 citations

    14

    h-index

  3. SH
    Samuel H. Gellman

    University of Wisconsin–Madison, United States

    13 publications · 1.2K citations

    13

    h-index

  4. PS
    Paramjit S. Arora

    New York University, United States

    11 publications · 1.2K citations

    11

    h-index

  5. DP
    David P. Fairlie

    The University of Queensland, Australia

    8 publications · 405 citations

    8

    h-index

1–5 of 1K

Institutions

315

  1. Yale University

    New Haven, United States

    18 h-index

    86 publications

    9.5K citations

  2. University of Leeds

    Leeds, United Kingdom

    14 h-index

    86 publications

    4.2K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    83 publications

    2.9K citations

  4. University of Wisconsin–Madison

    Madison, United States

    13 h-index

    56 publications

    5.5K citations

  5. New York University

    New York, United States

    12 h-index

    40 publications

    4.2K citations

  6. The University of Queensland

    Brisbane, Australia

    8 h-index

    54 publications

    3.1K citations

  7. Inserm

    Paris, France

    8 h-index

    19 publications

    616 citations

  8. University of Oxford

    Oxford, United Kingdom

    7 h-index

    22 publications

    544 citations

1–8 of 315

Venues

  1. Journal of the American Chemical Society

    JACS · 38 publications · 4K citations

    35

    h-index

  2. Angewandte Chemie International Edition

    21 publications · 1.6K citations

    19

    h-index

  3. Organic & Biomolecular Chemistry

    12 publications · 522 citations

    11

    h-index

  4. Organic Letters

    OL · 10 publications · 499 citations

    10

    h-index

  5. Angewandte Chemie

    11 publications · 294 citations

    10

    h-index

1–5