Concepedia

Allosteric Switch Engineering

Allosteric Switch Engineering is a methodological framework within protein engineering that enables the rational design of regulatory proteins by introducing or modifying allosteric sites to control protein activity through conformational changes induced by effector molecules.

22

Publications

1.9K

Citations

129

Authors

51

Institutions

Publications per year

2017–2026

12

Parents

Publications

22

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

Aron M. Levin, D.L. Bates, Aaron M. Ring et al. · Nature · 2012 · 554 citations

, , +14

Reprogramming Control of an Allosteric Signaling Switch Through Modular Recombination

John E. Dueber, Brian J. Yeh, Kayam Chak et al. · Science · 2003 · 301 citations

, , +17

De novo design of bioactive protein switches

Robert A. Langan, Scott E. Boyken, Andrew H. Ng et al. · Nature · 2019 · 284 citations · Full text

, , +12

An engineered allosteric switch in leucine-zipper oligomerization

Lino C. Gonzalez, Joseph J. Plecs, Tom Alber · Nature Structural & Molecular Biology · 1996 · 109 citations

, , +13

A pore-forming protein with a metal-actuated switch

Barbara Walker, John J. Kasianowicz, Musti V. Krishnasastry et al. · Protein Engineering Design and Selection · 1994 · 87 citations

, , +15

1–5 of 22

Authors

129

  1. SE
    Selvakumar Edwardraja

    Pusan National University, South Korea

    3 publications · 100 citations

    3

    h-index

  2. KA
    Kirill Alexandrov

    The University of Queensland, Australia

    3 publications · 100 citations

    3

    h-index

  3. ZG
    Zhong Guo

    The University of Queensland, Australia

    3 publications · 100 citations

    3

    h-index

  4. SN
    Stewart N. Loh

    SUNY Upstate Medical University, United States

    2 publications · 73 citations

    2

    h-index

  5. WA
    Wayne A. Johnston

    The University of Queensland, Australia

    2 publications · 85 citations

    2

    h-index

1–5 of 129

Institutions

51

  1. Commonwealth Scientific and Industrial Research Organisation

    Canberra, Australia

    3 h-index

    14 publications

    540 citations

  2. Queensland University of Technology

    Brisbane, Australia

    3 h-index

    11 publications

    434 citations

  3. The University of Queensland

    Brisbane, Australia

    3 h-index

    11 publications

    483 citations

  4. ARC Centre of Excellence in Synthetic Biology

    Sydney, Australia

    3 h-index

    14 publications

    540 citations

  5. University of California, San Francisco

    San Francisco, United States

    2 h-index

    9 publications

    2.6K citations

  6. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    3 publications

    91 citations

  7. University of California, Berkeley

    Berkeley, United States

    2 h-index

    6 publications

    1.2K citations

  8. SUNY Upstate Medical University

    Syracuse, United States

    2 h-index

    5 publications

    203 citations

1–8 of 51

Venues

  1. Journal of the American Chemical Society

    JACS · 3 publications · 107 citations

    3

    h-index

  2. Nature

    2 publications · 838 citations

    2

    h-index

  3. ACS Chemical Biology

    1 publications · 57 citations

    1

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    1 publications · 17 citations

    1

    h-index

  5. eLife

    1 publications · 55 citations

    1

    h-index

1–5