Concepedia

Allosteric Probes

Allosteric Probes is a chemical probe that selectively binds to an allosteric site of a target protein, modulating its function through conformational changes distinct from orthosteric ligand interactions.

26

Publications

857

Citations

190

Authors

63

Institutions

Publications per year

2017–2026

8

Parents

Publications

26

Screening for GPCR Ligands Using Surface Plasmon Resonance

Iva Navrátilová, Jérémy Besnard, Andrew L. Hopkins · ACS Medicinal Chemistry Letters · 2011 · 91 citations · Full text

, , +17

A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1

Xiaoyan Wang, Dongsheng Liu, Ling Shen et al. · Journal of the American Chemical Society · 2021 · 84 citations

, , +15

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe

Paul R. Reid, Thomas M. Bridges, Douglas J. Sheffler et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 67 citations · Full text

, , +11

Allostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence for Two Subunit Conformations and Four Quaternary States

Dimitri Niks, E. Hilario, Adam Dierkers et al. · Biochemistry · 2013 · 55 citations · Full text

, , +17

Synthesis and Characterization of Allosteric Probes of Substrate Channeling in the Tryptophan Synthase Bienzyme Complex<sup>,</sup>

Huu Ngo, R. Harris, N. Kimmich et al. · Biochemistry · 2007 · 54 citations

, , +17

1–5 of 26

Authors

190

  1. HN
    Huu Ngo

    Max Planck Institute for Medical Research, Germany

    2 publications · 109 citations

    2

    h-index

  2. DN
    Dimitri Niks

    University of California, Riverside, United States

    2 publications · 109 citations

    2

    h-index

  3. MF
    Michael F. Dunn

    University of California, Riverside, United States

    2 publications · 109 citations

    2

    h-index

  4. PX
    Ping Xu

    Central South University, China

    1 publications · 26 citations

    1

    h-index

  5. PR
    Paul R. Reid

    Vanderbilt University Medical Center, United States

    1 publications · 67 citations

    1

    h-index

1–5 of 190

Institutions

63

  1. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    2 h-index

    14 publications

    627 citations

  2. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    6 publications

    146 citations

  3. Institute of Biophysics

    Beijing, China

    2 h-index

    9 publications

    460 citations

  4. Shanghai Institute of Materia Medica

    Pudong, China

    1 h-index

    4 publications

    120 citations

  5. University of Cagliari

    Cagliari, Italy

    1 h-index

    2 publications

    64 citations

  6. Max Planck Institute for Medical Research

    Heidelberg, Germany

    1 h-index

    11 publications

    594 citations

  7. University of Florence

    Florence, Italy

    1 h-index

    4 publications

    128 citations

  8. Eindhoven University of Technology

    Eindhoven, The Netherlands

    1 h-index

    5 publications

    55 citations

1–8 of 63

Venues

  1. Biochemistry

    4 publications · 182 citations

    4

    h-index

  2. Biosensors and Bioelectronics

    3 publications · 52 citations

    3

    h-index

  3. Biophysical Journal

    2 publications · 50 citations

    2

    h-index

  4. ACS Medicinal Chemistry Letters

    2 publications · 102 citations

    2

    h-index

  5. ACS Chemical Biology

    2 publications · 64 citations

    2

    h-index

1–5