Concepedia

5-Alpha Reduction

5-Alpha Reduction is a metabolic reaction in which the enzyme 5α-reductase catalyzes the stereospecific reduction of the carbon-carbon double bond at the 4–5 position of steroid molecules, particularly converting testosterone to dihydrotestosterone, thereby increasing androgenic activity in target tissues.

146

Publications

5.6K

Citations

580

Authors

192

Institutions

Publications per year

2017–2026

4

Variants

5α-Reduction

Parents

Publications

146

Structure–activity relationships for inhibition of human 5α-reductases by polyphenols

Richard A. Hiipakka, Han‐Zhong Zhang, Wei Dai et al. · Biochemical Pharmacology · 2002 · 214 citations

, , +13

5 alpha-reduced androgens play a key role in murine parturition.

Mala Mahendroo, Kristine M. Cala, David W. Russell · Molecular Endocrinology · 1996 · 198 citations · Full text

, , +17

Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

Justine A. Ellis, Margaret Susanne Stebbing, Stephen Harrap · Journal of Investigative Dermatology · 1998 · 169 citations · Full text

, , +15

Selective-Inhibition of Steroid 5 α-Reductase Isozymes by Tea Epicatechin-3-Gallate and Epigallocatechin-3-Gallate

Shunyao Liao, Richard A. Hiipakka · Biochemical and Biophysical Research Communications · 1995 · 143 citations

, , +16

Increased 5α-reductase activity in idiopathic hirsutism

P. Serafini, Rogerio A. Løbo · Fertility and Sterility · 1985 · 135 citations

, , +9

1–5 of 146

Authors

580

  1. LM
    L. Martini

    University of Milan, Italy

    9 publications · 382 citations

    9

    h-index

  2. MA
    Mark A. Levy

    New Frontier, United States

    7 publications · 271 citations

    7

    h-index

  3. DA
    Dennis A. Holt

    New Frontier, United States

    7 publications · 271 citations

    7

    h-index

  4. MB
    Martín Brandt

    New Frontier, United States

    7 publications · 271 citations

    7

    h-index

  5. FC
    F. Celotti

    University of Milan, Italy

    6 publications · 242 citations

    6

    h-index

1–5 of 580

Institutions

192

  1. University of Southern California

    Los Angeles, United States

    9 h-index

    24 publications

    1K citations

  2. University of Milan

    Milan, Italy

    9 h-index

    34 publications

    1.6K citations

  3. New Frontier

    Fallon, United States

    6 h-index

    35 publications

    1.3K citations

  4. The University of Osaka

    Osaka, Japan

    5 h-index

    13 publications

    296 citations

  5. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    5 h-index

    27 publications

    1.6K citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    4 h-index

    7 publications

    616 citations

  7. Gunma University

    Maebashi, Japan

    3 h-index

    14 publications

    419 citations

  8. University of Arizona

    Tucson, United States

    3 h-index

    3 publications

    141 citations

1–8 of 192

Venues

  1. 12

    h-index

  2. Journal of Steroid Biochemistry

    14 publications · 407 citations

    12

    h-index

  3. Steroids

    11 publications · 294 citations

    11

    h-index

  4. Endocrinology

    6 publications · 179 citations

    6

    h-index

  5. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 6 publications · 213 citations

    6

    h-index

1–5