Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, +25

Nature Medicine

ProbioticDysbiosisHealth SciencesMedicineMicrobiota +12

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection<i>in vitro</i>and<i>in vivo</i>

Julie Strizki, Serena Xu, Nicole Wagner, +22

Proceedings of the National Academy of Sciences

Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells

Lei Miao, Jingjing Qi, Qi Zhao, +9

Theranostics

Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice

Bin Li, Wei Cui, Jia Liu, +8

Experimental Neurology

InflammationAutoimmune DiseaseTh17-related InflammationMedicineImmunology +7

Pollution characteristics of livestock faeces and the key driver of the spread of antibiotic resistance genes

Zhengfu Yue, Jing Zhang, Zhigao Zhou, +5

Journal of Hazardous Materials

Antimicrobial Resistance GeneAntimicrobial SusceptibilityPollution CharacteristicsVeterinary MicrobiologyMicrobiology +7

Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells

Limin Wei, Jianfeng Wang, Aijie Chen, +3

International Journal of Nanomedicine

oxLDL induces injury and defenestration of human liver sinusoidal endothelial cells via LOX1

Qi Zhang, Jing Liu, Jia Liu, +5

Journal of Molecular Endocrinology

Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8+ T Cells and Efficiently Reduces Chronic Retroviral Loads

Kirsten K. Dietze, Gennadiy Zelinskyy, Jia Liu, +3

PLoS Pathogens

Single‐Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus

Jia Liu, Mingyue Xu, Bo Tang, +7

Small

Viral ReplicationBunyavirus InfectionViral PathogenesisImmunologyMolecular Biology +19

Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

Jayaram R. Tagat, Stuart W. McCombie, Ruo W. Steensma, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryKey Pharmacophore ElementMedicineImmunologyAntiviral Therapy +9