Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis

Kai-Kai Zhang, Jian-Zheng Yang, Lijian Chen, +9

ACS Nano

DysbiosisHost-microbe InteractionsPathologyGut Microbiota ParticipatesInflammation +22

Methamphetamine reduces expressions of tight junction proteins, rearranges F-actin cytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway

Ye Xue, Jie-Tao He, Kai-Kai Zhang, +3

Biochemical and Biophysical Research Communications

Tight Junction ProteinsNeurophysiologyNeuroanatomyMedicinePhysiology +10

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

Kai-Kai Zhang, Lijian Chen, Jian-Zheng Yang, +9

Acta Pharmaceutica Sinica B

Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice

Lijian Chen, Xu Zhi, Kai-Kai Zhang, +7

Food and Chemical Toxicology

Substance AbusePsychoactive DrugAddictionPharmacologyClub Drug +4

Epigallocatechin-3-gallate ameliorates polystyrene microplastics-induced anxiety-like behavior in mice by modulating gut microbe homeostasis

Jian-Zheng Yang, Kai-Kai Zhang, Yi Liu, +9

The Science of The Total Environment

MedicinePathologyGut-organ AxisEpigallocatechin-3-gallate AmelioratesToxicology +4

Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats

Xiao-Hui Tan, Kai-Kai Zhang, Jingtao Xu, +6

Food and Chemical Toxicology

Psychoactive DrugMedicineApoptosisAutophagyPi3k/akt Pathway-modulated Apoptosis +8

Gestational exposure to GenX induces hepatic alterations by the gut-liver axis in maternal mice: A similar mechanism as PFOA

Lingling Xu, Yu-Kui Chen, Qin-Yao Zhang, +6

The Science of The Total Environment

Developmental BiologyHepatologyLiver PhysiologyGut-liver AxisDevelopmental Toxicology +9

Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats

Kai-Kai Zhang, Hui Wang, Dong Qu, +9

Frontiers in Pharmacology

Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice

Libin Wang, Lingling Xu, Lijian Chen, +7

Toxicology and Applied Pharmacology

InflammationChronic Inflammatory DiseasesDysbiosisMucosal ImmunologyIntestinal Injury +10

PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats

Xiao‐Li Xie, Wentao Zhou, Kai-Kai Zhang, +4

Chemosphere

HepatologyMedicineLiver PhysiologyApoptosisPcb52 Induces Hepatotoxicity +11