Neuraminidase-1, a Subunit of the Cell Surface Elastin Receptor, Desialylates and Functionally Inactivates Adjacent Receptors Interacting with the Mitogenic Growth Factors PDGF-BB and IGF-2

Aleksander Hinek, Tetyana D. Bodnaruk, Severa Bunda, +2

American Journal Of Pathology

Developmental BiologySignal TransductionCell AdhesionReceptor (Biochemistry)Cell-matrix Interaction +8

Retrovirally Mediated Overexpression of Versican V3 Reverses Impaired Elastogenesis and Heightened Proliferation Exhibited by Fibroblasts from Costello Syndrome and Hurler Disease Patients

Aleksander Hinek, Kathy R. Braun, Kela Liu, +2

American Journal Of Pathology

FibrosisMediated OverexpressionAutoimmune DiseaseDisease MechanismPathogenesis +7

Ellagic and Tannic Acids Protect Newly Synthesized Elastic Fibers from Premature Enzymatic Degradation in Dermal Fibroblast Cultures

Felipe Jimenez, Thomas F. Mitts, Kela Liu, +2

Journal of Investigative Dermatology

Tissue EngineeringEngineeringDermal Fibroblast CulturesWound HealingBiomedical Engineering +6

Aldosterone Stimulates Elastogenesis in Cardiac Fibroblasts via Mineralocorticoid Receptor-independent Action Involving the Consecutive Activation of Gα13, c-Src, the Insulin-like Growth Factor-I Receptor, and Phosphatidylinositol 3-Kinase/Akt

Severa Bunda, Yanting Wang, Thomas F. Mitts, +4

Journal of Biological Chemistry

Cardiac MuscleMolecular PhysiologyMedicineAldosterone Stimulates ElastogenesisPhysiology +11

Aldosterone Induces Elastin Production in Cardiac Fibroblasts through Activation of Insulin-Like Growth Factor-I Receptors in a Mineralocorticoid Receptor-Independent Manner

Severa Bunda, Peter Liu, Yanting Wang, +2

American Journal Of Pathology

Cardiac MuscleCardiomyopathyMedicinePhysiologyCardiac Fibroblasts +8

Sodium l-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin

Aleksander Hinek, Hyunjun J. Kim, Yanting Wang, +2

Journal of Dermatological Science

MechanobiologyEngineeringCutaneous BiologyPhysiologySkin Substitute +8

Proteolytic digest derived from bovine Ligamentum Nuchae stimulates deposition of new elastin-enriched matrix in cultures and transplants of human dermal fibroblasts

Aleksander Hinek, Yanting Wang, Kela Liu, +2

Journal of Dermatological Science

Regenerative MedicineTissue EngineeringHuman Dermal FibroblastsNew Elastin-enriched MatrixHuman Tissue +10

JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model

Qing Liu, Wanli Xie, Yanting Wang, +5

Laboratory Investigation

InflammationAcute Lung InjuryCytokineInflammatory Lung DiseaseLung Inflammation +9

Gastrodin exerts perioperative myocardial protection by improving mitophagy through the PINK1/Parkin pathway to reduce myocardial ischemia-reperfusion injury

Lu Chen, Yong Lv, Hui-liang Wu, +11

Phytomedicine

Insulin Induces Production of New Elastin in Cultures of Human Aortic Smooth Muscle Cells

Junyan Shi, Andrew Wang, Sanjana Sen, +4

American Journal Of Pathology

MechanobiologyMolecular PhysiologyInsulin Induces ProductionMedicinePhysiology +7