A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

Katherine M. Bruner, Zheng Wang, Francesco R. Simonetti, +23

Nature

Viral PersistenceViral DiagnosticsHuman RetrovirusImmunologyQuantitative Approach +6

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Kai Deng, Mihaela Pertea, Anthony Rongvaux, +20

Nature

Primary ImmunodeficiencyClear Latent Hiv-1Human RetrovirusImmunologyAntiviral Response +10

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

Hung‐Chih Yang, Sifei Xing, Liang Shan, +10

Journal of Clinical Investigation

EngineeringReverse LatencyImmunologyMolecular BiologyImmunotherapy +18

Stability of the Latent Reservoir for HIV‐1 in Patients Receiving Valproic Acid

Janet D. Siliciano, Jun Lai, Marc Callender, +8

The Journal of Infectious Diseases

Translational MedicineValproic AcidViral PersistenceNeurovirologyHuman Retrovirus +13

Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo

Francesco R. Simonetti, Hao Zhang, Garshasb Soroosh, +17

Journal of Clinical Investigation

Adaptive Immune SystemImmunologyImmune RegulationImmunodominanceCd4 T Cell Responses +17

Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target

Runxia Liu, Yang-Hui Jimmy Yeh, Ales Varabyou, +21

Science Translational Medicine

Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2)

Hao Zhang, Xiaolin Li, Jing Ding, +6

International Journal of Pharmaceutics

NanomedicineGastric Cancer CellsTherapeutic NanomaterialsPolymeric NanoparticlesPolymer-drug Conjugate +5

Different human resting memory CD4 ⁺ T cell subsets show similar low inducibility of latent HIV-1 proviruses

Kyungyoon J. Kwon, Andrew E. Timmons, Srona Sengupta, +6

Science Translational Medicine

Advancements in electrochemical synthesis: Expanding from water electrolysis to dual-value-added products

Genxiang Wang, Ao Chen, Yao Chen, +5

eScience

Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia

Jennifer A. White, Fengting Wu, Saif Yasin, +27

Journal of Clinical Investigation