Dimitri Shcherbakov

Premature aging in mice with error-prone protein synthesis

Dimitri Shcherbakov, Martina Nigri, Rashid Akbergenov et al. · Science Advances · 2022 · 62 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens

Takahiko Matsushita, Girish C. Sati, Nuwan Kondasinghe et al. · Journal of the American Chemical Society · 2019 · 54 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Identification and Evaluation of Improved 4′-<i>O</i>-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

Stefan Duscha, Heithem Boukari, Dimitri Shcherbakov et al. · mBio · 2014 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Apralogs: Apramycin 5-<i>O</i>-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant

Jonathan C.K. Quirke, Parasuraman Rajasekaran, Vikram A. Sarpe et al. · Journal of the American Chemical Society · 2019 · 40 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Structure-Based Design and Synthesis of Apramycin–Paromomycin Analogues: Importance of the Configuration at the 6′-Position and Differences between the 6′-Amino and Hydroxy Series

Appi Reddy Mandhapati, Guanyu Yang, Takayuki Kato et al. · Journal of the American Chemical Society · 2017 · 39 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16