Jonathan C.K. Quirke

Apralogs: Apramycin 5-<i>O</i>-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant

Jonathan C.K. Quirke, Parasuraman Rajasekaran, Vikram A. Sarpe et al. · Journal of the American Chemical Society · 2019 · 39 citations · Full text

An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity

Amr Sonousi, Jonathan C.K. Quirke, Prabuddha Waduge et al. · ChemMedChem · 2020 · 25 citations · Full text

Glycoside Hydrolases Restrict the Side Chain Conformation of Their Substrates To Gain Additional Transition State Stabilization

Jonathan C.K. Quirke, David Crich · Journal of the American Chemical Society · 2020 · 23 citations · Full text

Side Chain Conformation Restriction in the Catalysis of Glycosidic Bond Formation by Leloir Glycosyltransferases, Glycoside Phosphorylases, and Transglycosidases

Jonathan C.K. Quirke, David Crich · ACS Catalysis · 2021 · 17 citations · Full text

Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors

Aslamuzzaman Kazi, Alok Ranjan, Vasantha Kumar M.V. et al. · Cancer Research Communications · 2023 · 17 citations · Full text