Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma

Jia‐Cheng Lu, Pengfei Zhang, Xiaoyong Huang, +12

Journal of Hematology & Oncology

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein

Jingyou Yu, Minghua Li, Jordan Wilkins, +8

Cell Reports

Viral ReplicationImmunologyEnvelope GlycoproteinViral Structural ProteinImmunotherapy +14

PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma

Chuanyuan Wei, Meng-Xuan Zhu, Pengfei Zhang, +17

Journal of Hepatology

circHMGCS1–016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma

Yaping Xu, Ze-Ning Dong, Siwei Wang, +11

Journal of Experimental & Clinical Cancer Research

PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy

Yi-Min Zheng, Yining Wang, Lu Zhou, +11

Advanced Science

Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins

Jin Qian, Yann Le Duff, Yimeng Wang, +5

Virology

PathogenesisViral PathogenesisImmunologyAntiviral ResponseVirology +3

Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

Jia‐Cheng Lu, Lei‐Lei Wu, Yining Sun, +27

Nature Communications

HepatologyMacro Cd5l+MedicineLiver PhysiologyHepatobiliary Tumor +9

WDR4/TRIM28 is a novel molecular target linked to lenvatinib resistance that helps retain the stem characteristics in hepatocellular carcinomas

Weiyu Han, Jie Wang, Jing Zhao, +8

Cancer Letters

OncologyNovel Molecular TargetStem CharacteristicsMedicinePathology +7

Inhibition of Hepatitis C Virus Replication In Vitro by Xanthohumol, A Natural Product Present in Hops

Sai Lou, Yi-Min Zheng, Shan‐Lu Liu, +7

Planta Medica

Hepatic DisordersHepatologyCell Culture SystemHepatitis C VirusViral Hepatitis +12

Proteomic and metabolomic features in patients with HCC responding to lenvatinib and anti-PD1 therapy

Zhong-Chen Li, Jie Wang, He-Bin Liu, +16

Cell Reports

OncologyUhcc RespondersMedicineImmunologyMetabolomic Profiling +13