TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice

Yuko Ono, Yuko Maejima, Masafumi Saito, +5

Scientific Reports

Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis

Masafumi Saito, Yoshihisa Fujinami, Yuko Ono, +5

Brain Behavior and Immunity

Sepsis-associated EncephalopathyT-regulatory CellImmune RegulationImmunologyRegulatory T Cells +26

IL-15 Improves Aging-Induced Persistent T Cell Exhaustion in Mouse Models of Repeated Sepsis

Masafumi Saito, Shigeaki Inoue, Kimihiro Yamashita, +3

Shock

Sepsis-induced T ExhaustionImmune RegulationImmunologySepsis SurvivorsCd4 T Cell Responses +17

The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate–activated protein kinase activity and lipogenic gene expression in high-fat diet–fed obese mice

Tetsuo Saito, Miyako Nishida, Masafumi Saito, +5

Nutrition Research

ObesityNutritionMetabolic SyndromeAcanthopanax SenticosusLipid Nutrition +12

Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial

Masafumi Saito, Tohru Nemoto, Satoshi Tobimatsu, +3

Journal of Nutrition and Metabolism

Reduced Number and Immune Dysfunction of CD4+ T Cells in Obesity Accelerate Colorectal Cancer Progression

Kota Yamada, Masafumi Saito, Masayuki Ando, +13

Cells

Diacylglycerol kinase‐dependent formation of phosphatidic acid molecular species during interleukin‐2 activation in CTLL‐2 T‐lymphocytes

Satoru Mizuno, Hiromichi Sakai, Masafumi Saito, +2

FEBS Open Bio

Independent association between low serum amylase and non-alcoholic fatty liver disease in asymptomatic adults: a cross-sectional observational study

Kei Nakajima, Haruki Oshida, Toshitaka Muneyuki, +5

BMJ Open

Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

Naoto Tatewaki, Tetsuya Konishi, Yuki Nakajima, +6

PLoS ONE

Molecular RegulationMolecular BiologyCell DeathCell CycleTumor Biology +15

C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice

Yuko Ono, Masafumi Saito, K. Sakamoto, +6

Frontiers in Pharmacology