Jefferson Tilley

Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia

Martha J. Kelly, Sherrie Pietranico-Cole, J. Douglas Larigan et al. · Journal of Medicinal Chemistry · 2014 · 215 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Generation of an LFA-1 Antagonist by the Transfer of the ICAM-1 Immunoregulatory Epitope to a Small Molecule

Thomas R. Gadek, Daniel J. Burdick, Robert S. McDowell et al. · Science · 2002 · 170 citations

Life Sciences, Immunology, Pharmacology +17

Identification of a Small Molecule Inhibitor of the IL-2/IL-2Rα Receptor Interaction Which Binds to IL-2

Jefferson Tilley, Li Chen, David C. Fry et al. · Journal of the American Chemical Society · 1997 · 128 citations

Life Sciences, Medicinal Chemistry, Pharmacology +13

A convenient palladium-catalyzed coupling approach to 2,5-disubstituted pyridines

Jefferson Tilley, Sonja Zawoiski · The Journal of Organic Chemistry · 1988 · 113 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Glucokinase activators as new type 2 diabetes therapeutic agents

Ramakanth Sarabu, Steven J. Berthel, Robert F. Kester et al. · Expert Opinion on Therapeutic Patents · 2008 · 59 citations

Medicine, Biochemistry, Pharmacology +12