The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

G J Zaman, M J Flens, Manuel R. van Leusden, +7

Proceedings of the National Academy of Sciences

Molecular PharmacologyProtein MrpDrug Resistance AnalysisProteinlipid InteractionBiochemistry +13

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

G J Zaman, C. H. M. Versantvoort, Jasper Smit, +7

Lung Cancer

MedicineCancer BiologyAnti-cancer AgentProtein TransportPharmacology +4

Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia

CS Spier, TM Grogan, Charles A. Johnson, +7

Blood

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

Paul van der Valk, C.K. van Kalken, Henk A. M. Ketelaars, +7

Annals of Oncology

Tumor BiologyNeoplastic Human TissuesGlycosylationMedicinePathology +6

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

WS Dalton, TM Grogan, JA Rybski, +6

Blood

ATP‐dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion

N Feller, HJ Broxterman, D. C. R. Wahrer, +1

FEBS Letters

Intracellular Glutathione DepletionLipid PeroxidationMetabolic RemodelingCellular PhysiologyOxidative Stress +16

Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry

N Feller, C.M. Kuiper, J. Lankelma, +3

British Journal of Cancer

Tumor BiologyFlow CytometryMrp/p190-mediated Multidrug ResistanceMedicinePharmacology +9

Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein

Jan Hendrik Hooijberg, HJ Broxterman, Marc Heijn, +3

FEBS Letters

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein

GJ Schuurhuis, HJ Broxterman, JHM de Lange, +8

British Journal of Cancer

Antimicrobial Resistance GeneBiochemistryMedicineIntracellular Doxorubicin DistributionAntibiotic Resistance +4

The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification.

ML Slovak, J. Pelkey Ho, Susan P.C. Cole, +6

PubMed

Gene AmplificationGeneticsGenomic MechanismMolecular BiologyPathology +18