CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

Ravindra Majeti, Mark P. Chao, Ash A. Alizadeh, +5

Cell

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaMalignant Blood DisorderHematology +10

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Raúl Mostoslavsky, Katrin F. Chua, David B. Lombard, +28

Cell

Lifespan ExtensionChromatinGenome InstabilityGeneticsAging-like Phenotype +8

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

Siddhartha Jaiswal, Catriona Jamieson, Wendy W. Pang, +6

Cell

Cd47 IsHematological MalignancyMedicineMalignant Blood DisorderImmunology +8

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

Wendy W. Pang, Elizabeth Price, Debashis Sahoo, +5

Proceedings of the National Academy of Sciences

AgingYoung HscAdult Stem CellImmunologyBone Marrow Failure +15

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

Wendy W. Pang, John V. Pluvinage, Elizabeth Price, +6

Proceedings of the National Academy of Sciences

ImmunologyImmunotherapyAplastic AnemiaMyeloid NeoplasiaHematopoietic Stem Cell +16

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

Katrin F. Chua, Raúl Mostoslavsky, David B. Lombard, +10

Cell Metabolism

Genome InstabilityGenotoxic StressImmunologyCell DeathCellular Senescence +4

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

Agnieszka Czechowicz, Rahul Palchaudhuri, Amelia Scheck, +13

Nature Communications

BLT-humanized C57BL/6 Rag2−/−γc−/−CD47−/− mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection

Kerry J. Lavender, Wendy W. Pang, Ronald J. Messer, +11

Blood

Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice

Wendy W. Pang, Agnieszka Czechowicz, Aaron C. Logan, +5

Blood

Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome

Kelly A. McGowan, Wendy W. Pang, Rashmi Bhardwaj, +8

Blood