Junyu Lai

Discovery of 4-Aryl-<i>N</i>-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of in Vitro Potencies and Pharmacokinetic Properties

Ying-Shuan E. Lee, Shih‐Hsien Chuang, Lynn Y.L. Huang et al. · Journal of Medicinal Chemistry · 2014 · 39 citations · Full text

Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation

Junyu Lai, Manqing Ge, Sikui Shen et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2019 · 24 citations

Inflammation, Urology, Signal Transduction +9

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

Jianyu Liu, Yao-Yao Jiang, Peng-Jie Li et al. · Marine Life Science & Technology · 2024 · 22 citations · Full text

Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy

Shih‐Hsien Chuang, Ying-Shuan E. Lee, Lynn Y.L. Huang et al. · European Journal of Medicinal Chemistry · 2020 · 20 citations

First-in-class Clinical Candidate, T-1101 Tosylate, Hec1/nek2 Inhibition +11

β‐Adrenoceptor signaling regulates proliferation and contraction of human bladder smooth muscle cells under pathological hydrostatic pressure

Junyu Lai, Jianzhong Ai, Deyi Luo et al. · Journal of Cellular Biochemistry · 2019 · 15 citations