Ying-Shuan E. Lee

Discovery of 4-Aryl-<i>N</i>-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of in Vitro Potencies and Pharmacokinetic Properties

Ying-Shuan E. Lee, Shih‐Hsien Chuang, Lynn Y.L. Huang et al. · Journal of Medicinal Chemistry · 2014 · 39 citations · Full text

Copper(I)-Catalyzed Nitrile-Addition/<i>N</i>-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6<i>H</i>-indolo[3,2-<i>c</i>]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

Wen-Yun Hsueh, Ying-Shuan E. Lee, Min-Sian Huang et al. · Journal of Medicinal Chemistry · 2021 · 27 citations · Full text

Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy

Shih‐Hsien Chuang, Ying-Shuan E. Lee, Lynn Y.L. Huang et al. · European Journal of Medicinal Chemistry · 2020 · 20 citations

First-in-class Clinical Candidate, T-1101 Tosylate, Hec1/nek2 Inhibition +11

Nicotine Stimulates Expression of the PNMT Gene Through a Novel Promoter Sequence

Marian J. Evinger, Elizabeth Mathew, Štefan Číkoš et al. · Journal of Molecular Neuroscience · 2005 · 13 citations

Tobacco Control, Signal Transduction, Pnmt Gene +9

Synthesis and Antiproliferative Activities of Ottelione A Analogues

Tsai‐Yuan Chang, Yun-Peng Tu, Win‐Yin Wei et al. · ACS Medicinal Chemistry Letters · 2012 · 13 citations

Ottelione A Analogues, Medicinal Chemistry, Compound 10G +11