Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Barbara L. Cool, Bradley A. Zinker, William J. Chiou, +13

Cell Metabolism

Metabolic SyndromeSignal TransductionBiochemistryMedicineNatural Sciences +10

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

Harald Schmidt, Gerard D. Gagné, Masaki Nakane, +3

Journal of Histochemistry & Cytochemistry

NeurotransmitterNitrinergic Signal TransductionFrequent Co-localizationCellular PhysiologySocial Sciences +20

Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds

James M. Trevillyan, X. Grace Chiou, Yung‐Wu Chen, +13

Journal of Biological Chemistry

Reducing agent-mediated precipitation of high-abundance plasma proteins

Scott E. Warder, Lora A. Tucker, Tamara J. Strelitzer, +8

Analytical Biochemistry

High-abundance Plasma ProteinsProtein ChemistryBiochemistryNatural SciencesProteomics +1

Nitric Oxide Synthase in Bovine Superior Cervical Ganglion

Hong Sheng, Gerard D. Gagné, Takahiro Matsumoto, +3

Journal of Neurochemistry

Selective Antagonism of the ETA Receptor Reduces Neointimal Hyperplasia After Balloon-Induced Vascular Injury in Pigs

Sandra E. Burke, Nathan L. Lubbers, Gerard D. Gagné, +4

Journal of Cardiovascular Pharmacology

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes11Abbreviations: MMP, matrix metalloproteinase; MMPI, matrix metalloproteinase inhibitor; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; NBD-PE, N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; and MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; DMSO, dimethylsulfoxide; HPLC, high performance liquid chromatography.

Rebecca J. Gum, Dean Hickman, Jane A. Fagerland, +6

Biochemical Pharmacology

ABT-751, a novel tubulin-binding agent, decreases tumor perfusion and disrupts tumor vasculature

Yanping Luo, Vincent P. Hradil, David J. Frost, +7

Anti-Cancer Drugs

Tumor BiologyNovel Tubulin-binding AgentEndothelial CellsMuscle PerfusionMedicine +13

Computer-assisted imaging algorithms facilitate histomorphometric quantification of kidney damage in rodent renal failure models

Marcin Klapczynski, Gerard D. Gagné, Sherry J. Morgan, +5

Journal of Pathology Informatics

Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: In vitro properties, drug-likeness, and behavioral activity

Marlon Cowart, Gregory A. Gfesser, Kaitlin E. Browman, +22

Biochemical Pharmacology

Pharmacological StudyFunctional SelectivityMedicineBehavioral PharmacologyMechanism Of Action +8