Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry, +13

Nature

Protein FunctionBiochemistryIce/ced-3 ProteaseMedicineApoptosis +9

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

Mark Abramovitz, Mohammed Adam, Yves Boie, +16

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Related AnalogsSignal TransductionBiochemistryFunctional SelectivityMedicine +11

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

J. Rotonda, Donald W. Nicholson, Kimberly M. Fazil, +9

Nature Structural Biology

Protein FunctionSignal TransductionBiochemistryOrganelle DynamicNatural Sciences +10

Pharmacology of montelukast sodium (Singulair™), a potent and selective leukotriene D₄receptor antagonist

Thomas R. Jones, Marc Labelle, Michel Belley, +18

Canadian Journal of Physiology and Pharmacology

InflammationMolecular PharmacologyAnti-inflammatoryBiochemistryMedicine +12

Practical Route to a New Class of LTD₄ Receptor Antagonists

Robert D. Larsen, Edward G. Corley, Anthony O. King, +8

The Journal of Organic Chemistry

Key Diarylpropane FrameworkOrganic ChemistryPharmacotherapyChemistryMolecular Pharmacology +16

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.

Deborah Slipetz, Gary P. O’Neill, Leonard Favreau, +6

Molecular Pharmacology

Discovery of a Potent and Selective Prostaglandin D₂ Receptor Antagonist, [(3<i>R</i>)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[<i>b</i>]indol-3-yl]-acetic Acid (MK-0524)

Claudio F. Sturino, Gary P. O’Neill, Nicolas Lachance, +32

Journal of Medicinal Chemistry

Prostaglandin Receptor EP₄ Mediates the Bone Anabolic Effects of PGE₂

M. Machwate, Satoru Harada, Chih‐Tai Leu, +11

Molecular Pharmacology

Structure–activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor

Hélène Jûteau, Yves Gareau, Marc Labelle, +7

Bioorganic & Medicinal Chemistry

Structure–activity RelationshipMolecular PharmacologyBiochemistryMedicineMechanism Of Action +5

Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptors

Yves Gareau, Claude Dufresne, Michel Gallant, +7

Bioorganic & Medicinal Chemistry Letters

Cannabis UseBiochemistryG Protein-coupled ReceptorNatural SciencesMedicine +8