Atsushi Kurihara

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

Miho Kazui, Yumi Nishiya, Tomoko Ishizuka et al. · Drug Metabolism and Disposition · 2009 · 821 citations

Medicine, Biochemistry, Pharmacology +17

INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450

Jessica Rehmel, James A. Eckstein, Nagy A. Farid et al. · Drug Metabolism and Disposition · 2006 · 263 citations

Medicine, Biochemistry, Pharmacology +17

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

Shintaro Nakayama, Ryo Atsumi, Hideo Takakusa et al. · Drug Metabolism and Disposition · 2009 · 248 citations

Pharmacy, Pharmacology, Toxicology +17

The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel’s active metabolite

Atsuhiro Sugidachi, Taketoshi Ogawa, Atsushi Kurihara et al. · Journal of Thrombosis and Haemostasis · 2007 · 218 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16

The Disposition of Prasugrel, a Novel Thienopyridine, in Humans

Nagy A. Farid, Richard L. Smith, Todd A. Gillespie et al. · Drug Metabolism and Disposition · 2007 · 213 citations

Pharmacy, Pharmacokinetics, Pharmacology +15