Dual Metalloprotease Inhibitors:  Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

Jeffrey A. Robl, Chong‐Qing Sun, Jay Stevenson, +18

Journal of Medicinal Chemistry

HypertensionChemical BiologyMedicinal ChemistryCompound 1ADual Metalloprotease Inhibitors +15

Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats

Jacek Ostrowski, Joyce E. Kuhns, John A. Lupisella, +15

Endocrinology

Observed Tissue SelectivityPharmacotherapyPotent Hyperanabolic StimulationSkeletal MusclePotent Oral Activity +15

A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors

Jeffrey A. Robl, Richard Sulsky, Chong‐Qing Sun, +16

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryNovel SeriesBiochemistryPharmacological Study +11

Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

James J. Li, James Sutton, Alexandra A. Nirschl, +19

Journal of Medicinal Chemistry

Androgen ReceptorPharmacotherapyMedicinal ChemistryPharmacological StudyScaffold Modifications +17

Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an <i>N</i>-Aryl-hydroxybicyclohydantoin Scaffold

Chong‐Qing Sun, Jeffrey A. Robl, Tammy C. Wang, +16

Journal of Medicinal Chemistry

Androgen ReceptorDrug TargetPharmacotherapyChemical BiologyMedicinal Chemistry +15

Aminodiol HIV Protease Inhibitors. Synthesis And Structure−Activity Relationships Of P₁/P₁‘ Compounds:  Correlation between Lipophilicity and Cytotoxicity

Ping Chen, Peter T. W. Cheng, Masud Alam, +21

Journal of Medicinal Chemistry

Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

Bruce A. Ellsworth, Ying Wang, Yeheng Zhu, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceHydroxyl GroupBiochemistryMedicine +10

Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides

Jeffrey A. Robl, Ligaya M. Simpkins, Jay Stevenson, +9

Bioorganic & Medicinal Chemistry Letters

Chemical BiologyBiochemistryNatural SciencesPeptide LibraryPeptoid +3

The Guinea Pig as a Preclinical Model for Demonstrating the Efficacy and Safety of Statins

Cort S. Madsen, Evan B. Janovitz, Rongan Zhang, +22

Journal of Pharmacology and Experimental Therapeutics

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Lawrence G. Hamann, Mark C. Manfredi, Chong‐Qing Sun, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryFunctional SelectivityMedicine +9