IgA nephropathy and IgA vasculitis with nephritis have a shared feature involving galactose-deficient IgA1-oriented pathogenesis

Hitoshi Suzuki, Junichi Yasutake, Yuko Makita, +5

Kidney International

TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6–mediated pathways in IgA nephropathy

Yuko Makita, Hitoshi Suzuki, Toshiki Kano, +4

Kidney International

Renal PathologyImmunologyRenal InflammationInnate Immune SystemInnate Immunity +19

A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy

James R. Myette, Toshiki Kano, Hitoshi Suzuki, +10

Kidney International

GlomerulonephritisMurine Iga NephropathyAutoimmune DiseaseLupus NephritisIga Glomerulonephritis +12

Molecular insights into the early stage of glomerular injury in IgA nephropathy using single-cell RNA sequencing

Sonia Zambrano, Liqun He, Toshiki Kano, +6

Kidney International

Glomerular DiseaseImmunologyGlomerulonephritisSingle Cell SequencingIga Glomerulonephritis +14

Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA nephropathy patients

Daisuke Sato, Yasuhiro Suzuki, Toshiki Kano, +6

Nephrology Dialysis Transplantation

Nasal-associated lymphoid tissue is the major induction site for nephritogenic IgA in murine IgA nephropathy

Toshiki Kano, Hitoshi Suzuki, Yuko Makita, +2

Kidney International

Murine Iga NephropathyNephritogenic IgaIga GlomerulonephritisImmunologyPathology +6

The nucleotide-sensing Toll-Like Receptor 9/Toll-Like Receptor 7 system is a potential therapeutic target for IgA nephropathy

Mingfeng Lee, Hitoshi Suzuki, Kei Ogiwara, +10

Kidney International

Innate Immune SystemImmunologyInflammationToll-like ReceptorsGlomerulonephritis +15

Glomerular deposition of galactose-deficient IgA1-containing immune complexes via glomerular endothelial cell injuries

Yuko Makita, Hitoshi Suzuki, Daisuke Nakano, +5

Nephrology Dialysis Transplantation

Galactose-Deficient IgA1 as a Candidate Urinary Marker of IgA Nephropathy

Yusuke Fukao, Hitoshi Suzuki, Jin Sug Kim, +10

Journal of Clinical Medicine

Glomerular DiseaseSpecific Monoclonal AntibodyRenal PathologyImmunologyPathology +17

Renal pathological analysis using galactose-deficient IgA1-specific monoclonal antibody is a strong tool for differentiation of primary IgA nephropathy from secondary IgA nephropathy

Mingfeng Lee, Hitoshi Suzuki, Rina Kato, +5

CEN Case Reports