Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas

Davide Calebiro, Elisa Grassi, Markus Eszlinger, +15

Journal of Clinical Investigation

Epigenetic ChangeGeneticsMolecular BiologyPathologyMolecular Genetics +15

Evaluation of Small-Molecule Modulators of the Luteinizing Hormone/Choriogonadotropin and Thyroid Stimulating Hormone Receptors:  Structure−Activity Relationships and Selective Binding Patterns

Susanna Moore, Holger Jaeschke, Gunnar Kleinau, +10

Journal of Medicinal Chemistry

Chemical ModificationSelective Binding PatternsChemical BiologySmall-molecule ModulatorsMedicinal Chemistry +18

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort

Christoffer Löf, Konrad Patyra, Teemu Kuulasmaa, +20

Thyroid

Contacts between Extracellular Loop Two and Transmembrane Helix Six Determine Basal Activity of the Thyroid-stimulating Hormone Receptor

Gunnar Kleinau, Maren Claus, Holger Jaeschke, +4

Journal of Biological Chemistry

Molecular BiologyCellular PhysiologyAlanine MutationsSecretory PathwayEcl2 Mutants +17

Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor

Holger Jaeschke, Catherine L. Worth, Sandra Mueller, +3

PLoS ONE

Extended Hormone Binding Site of the Human Thyroid Stimulating Hormone Receptor

Sandra Mueller, Gunnar Kleinau, Holger Jaeschke, +2

Journal of Biological Chemistry

Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor

Gunnar Kleinau, Holger Jaeschke, Sandra Mueller, +4

The FASEB Journal

Full SignalingMolecular BiologyExtracellular LoopsCellular PhysiologySignaling Pathway +17

The Superagonistic Activity of Bovine Thyroid-stimulating Hormone (TSH) and the Human TR1401 TSH Analog Is Determined by Specific Amino Acids in the Hinge Region of the Human TSH Receptor

Sandra Mueller, Gunnar Kleinau, Mariusz W. Szkudlinski, +3

Journal of Biological Chemistry

A Hydrophobic Cluster in the Center of the Third Extracellular Loop Is Important for Thyrotropin Receptor Signaling

Maren Claus, Holger Jaeschke, Gunnar Kleinau, +3

Endocrinology

Molecular BiologyCellular PhysiologyHydrophobic ClusterThyrotropin ReceptorReceptor Tyrosine Kinase +18

Somatic mutations in 33 benign and malignant hot thyroid nodules in children and adolescents

Markus Eszlinger, Marek Niedziela, Eva Typlt, +8

Molecular and Cellular Endocrinology

Thyroid DisordersThyroid DiseaseSomatic MutationsThyroid Hormone