Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort

Christoffer Löf, Konrad Patyra, Teemu Kuulasmaa, +20

Thyroid

Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism

Hakan Cangül, Xiao-Hui Liao, Erik Schoenmakers, +23

JCI Insight

GeneticsMolecular BiologyMolecular GeneticsCongenital DeafnessMendelian Disorder +14

Transient Receptor Potential Canonical 1 (TRPC1) Channels as Regulators of Sphingolipid and VEGF Receptor Expression

Muhammad Yasir Asghar, Melissa Magnusson, Kati Kemppainen, +5

Journal of Biological Chemistry

Signal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled ReceptorReceptor Tyrosine Kinase +9

An autocrine sphingosine-1-phosphate signaling loop enhances NF-κB-activation and survival

Tomas Blom, Nina Bergelin, Annika Meinander, +4

BMC Cell Biology

Sphingosine Kinase as an Oncogene: Autocrine Sphingosine 1-Phoshate Modulates ML-1 Thyroid Carcinoma Cell Migration by a Mechanism Dependent on Protein Kinase C-α and ERK1/2

Nina Bergelin, Tomas Blom, Jari Heikkilä, +6

Endocrinology

S1P1 and VEGFR-2 Form a Signaling Complex with Extracellularly Regulated Kinase 1/2 and Protein Kinase C-α Regulating ML-1 Thyroid Carcinoma Cell Migration

Nina Bergelin, Christoffer Löf, S. Balthasar, +2

Endocrinology

Functional coupling of TRPC2 cation channels and the calcium‐activated anion channels in rat thyroid cells: Implications for iodide homeostasis

Tero Viitanen, Pramod Sukumaran, Christoffer Löf, +1

Journal of Cellular Physiology

Trpc2 Cation ChannelsCellular PhysiologyHyperpolarization (Biology)Shtrpc2 Knock-down CellsMembrane Transport +20

Interactions between sphingosine-1-phosphate and vascular endothelial growth factor signalling in ML-1 follicular thyroid carcinoma cells

S. Balthasar, Nina Bergelin, Christoffer Löf, +3

Endocrine Related Cancer

Human GrowthImmunologyCell ProliferationVegf-a SecretionTumor Biology +16

A mouse model with tamoxifen‐inducible thyrocyte‐specific cre recombinase activity

Henriette Undeutsch, Christoffer Löf, Stefan Offermanns, +1

genesis

GeneticsGene CharacterizationMolecular GeneticsMammary Gland DevelopmentTumor Biology +21

Significance of the transient receptor potential canonical 2 (TRPC2) channel in the regulation of rat thyroid FRTL-5 cell proliferation, migration, adhesion and invasion

Pramod Sukumaran, Christoffer Löf, Ilari Pulli, +3

Molecular and Cellular Endocrinology

Developmental BiologyMolecular PhysiologySignal TransductionSignaling PathwayCell Signaling +6