Synthesis and Evaluation of 1,2,3-Triazole Containing Analogues of the Immunostimulant α-GalCer

Tae‐Ho Lee, Minjae Cho, Sung‐Youl Ko, +5

Journal of Medicinal Chemistry

IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant

Xuguang Yin, Xiang-Zhao Chen, Wen-Mei Sun, +9

Organic Letters

EngineeringImmunologyImmunodominancePeptide ScienceImmunotherapeutics +22

Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier

Xiangru Wang, Ravi Maruvada, Andrew J. Morris, +5

PLoS Pathogens

Synthesis of selective inhibitors of sphingosine kinase 1

Dong Jae Baek, Neil MacRitchie, Nigel J. Pyne, +2

Chemical Communications

Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors

Dong Jae Baek, Neil MacRitchie, Nahoum G. Anthony, +4

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryStructure-activity Relationship ProfileCrystal StructureDrug Target +12

Allomyrina dichotoma larval extract attenuates intestinal barrier disruption by altering inflammatory response and tight junction proteins in lipopolysaccharide-induced Caco-2 cells

Kyong Kim, Gong Deuk Bae, Eun‐Young Park, +4

Biochemical and Biophysical Research Communications

InflammationSignal TransductionMucosal ImmunologyTight Junction ProteinsMedicine +12

An α-GalCer analogue with branched acyl chain enhances protective immune responses in a nasal influenza vaccine

Yoon Sook Lee, Kyoo‐A Lee, Jae‐Young Lee, +5

Vaccine

VaccinationNasal Influenza VaccineCross-protectionVaccine Developmentα-Galcer Analogue +9

Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics

Joanna M. Woodcock, Carl Coolen, Katy L. Goodwin, +5

Oncotarget

Protein AssemblyApoptosisNovel ApproachMolecular BiologyCell Death +25

Syntheses of sulfur and selenium analogues of pachastrissamine via double displacements of cyclic sulfate

Hongjun Jeon, Hoon Bae, Dong Jae Baek, +3

Organic & Biomolecular Chemistry

Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation

Gong Deuk Bae, Eun‐Young Park, Dong Jae Baek, +2

Biomedicine & Pharmacotherapy

Signal TransductionMedicineHormonal ReceptorApoptosisAutophagy +5