Nigel J. Pyne

Sphingosine 1-phosphate signalling in mammalian cells

Susan Pyne, Nigel J. Pyne · Biochemical Journal · 2000 · 481 citations

Sphingosine 1-Phosphate, Cell Death, Cellular Physiology +18

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

S P H Alexander, Doriano Fabbro, Eamonn Kelly et al. · British Journal of Pharmacology · 2023 · 423 citations · Full text

Drug Target, System Pharmacology, Pre-clinical Pharmacology +22

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

S P H Alexander, Doriano Fabbro, Eamonn Kelly et al. · British Journal of Pharmacology · 2021 · 380 citations · Full text

Drug Target, Cellular Pharmacology, System Pharmacology +19

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

Francesca Tonelli, Keng Gat Lim, Carolyn J. Loveridge et al. · Cellular Signalling · 2010 · 179 citations · Full text

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

Carol Watson, Jaclyn S. Long, Clare Orange et al. · American Journal Of Pathology · 2010 · 169 citations · Full text

Breast Oncology, Tamoxifen Resistance, Sphingosine Kinase 1 +11