Keng Gat Lim

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

Francesca Tonelli, Keng Gat Lim, Carolyn J. Loveridge et al. · Cellular Signalling · 2010 · 179 citations · Full text

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

Carolyn J. Loveridge, Francesca Tonelli, Tamara Leclercq et al. · Journal of Biological Chemistry · 2010 · 117 citations · Full text

Apoptosis, Cell Death, Cellular Physiology +16

(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells

Keng Gat Lim, Chaode Sun, Robert Bittman et al. · Cellular Signalling · 2011 · 98 citations

Hek 293, Breast Oncology, Signaling Pathway +9

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

Keng Gat Lim, Alexander I. Gray, Susan Pyne et al. · British Journal of Pharmacology · 2012 · 61 citations · Full text

KDM6B Counteracts EZH2-Mediated Suppression of <i>IGFBP5</i> to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer

Wenyu Wang, Keng Gat Lim, Min Feng et al. · Molecular Cancer Therapeutics · 2018 · 51 citations