Organic Letters · 2017 · 89 citations · 39 references
MedicineImmunologyOncologyCancer ImmunologyVaccine ImmunologyVaccinologyAntibody CharacterizationAntibody-antigen RecognitionCancer VaccinesTumor-associated AntigensVaccine Antigen DesignVaccine Antigen DiscoveryAntibody Class SwitchingCarbohydrate-based AdjuvantsConjugationSelf-adjuvanting VaccinesSynthetic VaccineTumor-associated Antigen VaccinesTumor-associated Carbohydrate AntigensVaccine Candidate Antigens
A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component vaccine STn-αGalCer is devoid of antigenic peptide, featuring the well-defined structure with high simplicity. STn-αGalCer showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes of IgG antibody were primarily IgG1 and IgG3.
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CD1d-Restricted and TCR-Mediated Activation of V <sub>α</sub> 14 NKT Cells by Glycosylceramides
Tetsu Kawano, Junqing Cui, Yasuhiko Koezuka et al. · Science · 1997 · 2.4K citations