R Nagai

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Toshimasa Yamauchi, Junji Kamon, Hironori Waki et al. · Nature Medicine · 2001 · 4.9K citations

Insulin Resistance, Metabolic Syndrome, Obesity +11

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi et al. · Nature Medicine · 2002 · 4.2K citations

Obesity, Biochemistry, Amp-activated Protein Kinase +9

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Naoto Kubota, Kazuyuki Tobe, Yasuo Terauchi et al. · Diabetes · 2000 · 524 citations · Full text

Insulin Receptor, Insulin Signaling, Causes Type 2 +20

Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.

Yukiko Kurihara, Hiroki Kurihara, H. Oda et al. · Journal of Clinical Investigation · 1995 · 388 citations · Full text

A Mouse Model of Vascular Injury that Induces Rapid Onset of Medial Cell Apoptosis Followed by Reproducible Neointimal Hyperplasia

M Sata, Y Maejima, F Adachi et al. · Journal of Molecular and Cellular Cardiology · 2000 · 304 citations

Angiogenesis, Apoptosis, Cell Death +9