Richard M. Pastor

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Matthew Volgraf, Benjamin D. Sellers, Yu Jiang et al. · Journal of Medicinal Chemistry · 2016 · 102 citations · Full text

Synaptic Transmission, Neurotransmitter, Synaptic Signaling +28

Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors

Emily J. Hanan, Anne van Abbema, Kathy Barrett et al. · Journal of Medicinal Chemistry · 2012 · 89 citations · Full text

Lead Compounds, Drug Target, Chemoprevention Strategy +19

Mutagenesis Study of Active Site Residues in Chorismate Mutase from <i>Bacillus subtilis</i>

Sharon T. Cload, David R. Liu, Richard M. Pastor et al. · Journal of the American Chemical Society · 1996 · 80 citations

Chorismate Mutase, Biochemistry, Natural Sciences +14

Analysis of Active Site Residues in <i>Escherichia coli</i> Chorismate Mutase by Site-Directed Mutagenesis

David R. Liu, Sharon T. Cload, Richard M. Pastor et al. · Journal of the American Chemical Society · 1996 · 64 citations

Biochemistry, Natural Sciences, Bacteriology +15

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors

Richard M. Pastor, Jason D. Burch, Steven Magnuson et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 19 citations · Full text

Medicinal Chemistry, Medicine, Immunology +4