The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Ling Lin, Juliette Faraco, Robin Li, +7

Cell

Sleep DisordersSleepSleep MedicineReceptor 2Sleep Disorder +5

Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8

Keith Gorden, Kevin Gorski, Sheila J. Gibson, +6

The Journal of Immunology

Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups

Emmanuel Mignot, Ling Lin, William M. Rogers, +12

The American Journal of Human Genetics

MedicineThree Ethnic GroupsAutoimmune DiseaseComplex Hla-dr

Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

Sheila J. Gibson, Jana M. Lindh, Tony R. Riter, +13

Cellular Immunology

InflammationCytokinePlasmacytoid Dendritic CellsImmunologyImmune Regulation +7

Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides

Keith Gorden, Xiaohong Qiu, Christine C. A. Binsfeld, +2

The Journal of Immunology

Innate Immune SystemImmunologyImmune RegulationImmunologic MechanismHuman Tlr7 +16

CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells

Mitchell G. Kluesner, Walker S. Lahr, Cara-lin Lonetree, +12

Nature Communications

Oligodeoxynucleotides Differentially Modulate Activation of TLR7 and TLR8 by Imidazoquinolines

Keith Gorden, Xiaohong Qiu, John J. L. Battiste, +3

The Journal of Immunology

Innate Immune SystemImmunologyMolecular BiologyImmunologic MechanismInnate Immunity +18

Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent

Nandita Bose, Anissa Chan, Faimola O. Guerrero, +13

Frontiers in Immunology

Microbial PathogensInnate Immune SystemGlycobiologyImmunologyImmune Regulation +25

Molecular basis for lack of expression of HLA class I antigens in human small-cell lung carcinoma cell lines

D. P. Singal, Ming Ye, Xiaohong Qiu

International Journal of Cancer

HlaHistocompatibilityLmp2 GenesHla ImmunogeneticsImmunology +18

Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

Anissa Chan, Adria Bykowski Jonas, Xiaohong Qiu, +13

PLoS ONE

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismWhole Blood +18