Biothera (United States)

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

Helen S. Goodridge, Christopher N. Reyes, Courtney Becker et al. · Nature · 2011 · 825 citations

Innate Immune System, Immunology, Immunologic Mechanism +6

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

Shira Cramer, Achinto Saha, Jinyun Liu et al. · Nature Medicine · 2016 · 521 citations

Systemic Depletion, Inase Increases, Pathology +7

Dabrafenib in patients with BRAFV600E-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial

David Planchard, Tae Min Kim, Julien Mazières et al. · The Lancet Oncology · 2016 · 439 citations · Full text

Oncology, Non-small-cell Lung Cancer, Pathology +7

Comparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor–Positive Breast Cancer

Ivana Šestak, Richard Buus, Jack Cuzick et al. · JAMA Oncology · 2018 · 322 citations · Full text

Molecular Characterization of a Human DNA Kinase

Feridoun Karimi‐Busheri, Graham Daly, Peter Robins et al. · Journal of Biological Chemistry · 1999 · 235 citations · Full text