Latent TGF-β structure and activation

Minlong Shi, Jianghai Zhu, Rui Wang, +4

Nature

Signal TransductionCell GrowthMedicineCell BiologyCell Signaling +1

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

Jianghai Zhu, Bing‐Hao Luo, Tsan Sam Xiao, +3

Molecular Cell

MechanobiologyComplete Integrin EctodomainBiophysical ModelingMolecular PhysiologyEngineering +12

Force interacts with macromolecular structure in activation of TGF-β

Xianchi Dong, Bo Zhao, Roxana E. Iacob, +5

Nature

MechanobiologyMacromolecular StructureSignal TransductionBiomolecular InteractionCell Biomechanics +6

Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3

Timothy A. Springer, Jianghai Zhu, Tsan Sam Xiao

The Journal of Cell Biology

Protein AssemblyMolecular BiologyFibrinogen γC PeptidePeptide SciencePlatelet Aggregation +16

Complete integrin headpiece opening in eight steps

Jieqing Zhu, Jianghai Zhu, Timothy A. Springer

The Journal of Cell Biology

Structure of an integrin with an αI domain, complement receptor type 4

Can Xie, Jianghai Zhu, Xing Chen, +3

The EMBO Journal

Complement SystemSignal TransductionαI DomainImmunologyReceptor (Biochemistry) +4

GARP regulates the bioavailability and activation of TGFβ

Rui Wang, Jianghai Zhu, Xianchi Dong, +3

Molecular Biology of the Cell

Latent TgfβProtein FunctionSignal TransductionSignaling PathwayG Protein-coupled Receptor +11

Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening

Jieqing Zhu, Jianghai Zhu, Ana Negri, +4

Blood

Structural specializations of α4β7, an integrin that mediates rolling adhesion

Yamei Yu, Jianghai Zhu, Li-Zhi Mi, +4

The Journal of Cell Biology

Structure-Guided Design of a High-Affinity Platelet Integrin α _IIb β ₃ Receptor Antagonist That Disrupts Mg ²⁺ Binding to the MIDAS

Jieqing Zhu, Won Suk Choi, Joshua G. McCoy, +13

Science Translational Medicine