N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

F. Tian, Bei Tong, Liang Sun, +5

eLife

Force interacts with macromolecular structure in activation of TGF-β

Xianchi Dong, Bo Zhao, Roxana E. Iacob, +5

Nature

MechanobiologyMacromolecular StructureSignal TransductionBiomolecular InteractionCell Biomechanics +6

GARP regulates the bioavailability and activation of TGFβ

Rui Wang, Jianghai Zhu, Xianchi Dong, +3

Molecular Biology of the Cell

Latent TgfβProtein FunctionSignal TransductionSignaling PathwayG Protein-coupled Receptor +11

Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3

Peng Zhang, Jiamu Du, Bingfa Sun, +7

Nucleic Acids Research

Structural determinants of integrin β-subunit specificity for latent TGF-β

Xianchi Dong, Nathan E. Hudson, Chafen Lu, +1

Nature Structural & Molecular Biology

Signal TransductionCell AdhesionIntegrin β-Subunit SpecificityCell-matrix InteractionMedicine +3

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Abhay Kotecha, Quan Wang, Xianchi Dong, +10

Nature Communications

Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

F. Tian, Bei Tong, Liang Sun, +5

Virus StructureMolecular DynamicsSpike ProteinViral EvolutionAbstract Sars-cov-2 +13

The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis

Xianchi Dong, Nina C. Leksa, Ekta Seth Chhabra, +5

Blood

α_Vβ₃ Integrin Crystal Structures and Their Functional Implications

Xianchi Dong, Li-Zhi Mi, Jianghai Zhu, +4

Biochemistry

Integrin HeadpieceElectron DensityCrystal StructureEngineeringBiochemistry +13

Structural Basis of Regulation of von Willebrand Factor Binding to Glycoprotein Ib

Mark Blenner, Xianchi Dong, Timothy A. Springer

Journal of Biological Chemistry