John B. Hynes

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.

G R Westerhof, Jan H. Schornagel, Ietje Kathmann et al. · Molecular Pharmacology · 1995 · 205 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Endocytosis of GPI-linked membrane folate receptor-alpha.

S Rijnboutt, Gerrit Jansen, George Posthuma et al. · The Journal of Cell Biology · 1996 · 190 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Purification of mammalian tumor (L1210) thymidylate synthetase by affinity chromatography on stable biospecific adsorbent. Stabilization of the enzyme with neutral detergents.

Wojciech Rode, Kevin J. Scanlon, John B. Hynes et al. · Journal of Biological Chemistry · 1979 · 64 citations · Full text

Life Sciences, Biochemistry, Cancer Biology +17

Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids

John B. Hynes, Donald E. Eason, Claudia M. Garrett et al. · Journal of Medicinal Chemistry · 1977 · 42 citations

Life Sciences, Medicinal Chemistry, Pharmacology +7

Quantitative structure-activity relation of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines

Corwin Hansch, James Y. Fukunaga, P. Y. C. JOW et al. · Journal of Medicinal Chemistry · 1977 · 35 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7