Complement C1q Activates Tumor Suppressor WWOX to Induce Apoptosis in Prostate Cancer Cells

Qunying Hong, Chun‐I Sze, Sing-Ru Lin, +8

PLoS ONE

Transforming Growth Factor β1 Signaling via Interaction with Cell Surface Hyal-2 and Recruitment of WWOX/WOX1

Li‐Jin Hsu, Lori Schultz, Qunying Hong, +10

Journal of Biological Chemistry

Dramatic Co-Activation of WWOX/WOX1 with CREB and NF-κB in Delayed Loss of Small Dorsal Root Ganglion Neurons upon Sciatic Nerve Transection in Rats

Meng-Yen Li, Feng-Jie Lai, Li‐Jin Hsu, +11

PLoS ONE

Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed

Li‐Jin Hsu, Qunying Hong, Shur-Tzu Chen, +10

Oncotarget

Cell DeathPathologyCancer BiologyCellular PhysiologyTumor Biology +22

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain

Jean-Yun Chang, Ming-Hui Lee, Sing‐Ru Lin, +10

Oncotarget

Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial

Wei Peng Yong, Sun Young Rha, Iain BeeHuat Tan, +18

Clinical Cancer Research

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Pei-Yi Chou, Sing-Ru Lin, Ming-Hui Lee, +3

Cell Communication and Signaling

Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria

Li‐Jin Hsu, Qunying Hong, Lori Schultz, +5

Cellular Signalling

BiochemistryMitochondrial FunctionMedicineCell DeathReactive Oxygen Specie +6

Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo

Wan-Pei Su, Wan-Jen Wang, Jean-Yun Chang, +15

Cancers

ImmunologyCell DeathSynthetic Zfra4-10Spleen Z CellsCancer Biology +15

Zfra activates memory Hyal-2+ CD3− CD19− spleen cells to block cancer growth, stemness, and metastasis<i>in vivo</i>

Ming-Hui Lee, Wan-Pei Su, Wan-Jen Wang, +18

Oncotarget

Tumor Necrosis FactorMedicineImmunologyZfra AggregationCancer Cell Biology +12