Hyaluronidase Induction of a WW Domain-containing Oxidoreductase That Enhances Tumor Necrosis Factor Cytotoxicity

Nan‐Shan Chang, Nicole Pratt, John K. Heath, +4

Journal of Biological Chemistry

WOX1 Is Essential for Tumor Necrosis Factor-, UV Light-, Staurosporine-, and p53-mediated Cell Death, and Its Tyrosine 33-phosphorylated Form Binds and Stabilizes Serine 46-phosphorylated p53

Nan‐Shan Chang, Joan Doherty, Amy Ensign, +3

Journal of Biological Chemistry

Down-regulation of WW Domain-containing Oxidoreductase Induces Tau Phosphorylation in Vitro

Chun‐I Sze, Meng Su, Subbiah Pugazhenthi, +5

Journal of Biological Chemistry

Complement C1q Activates Tumor Suppressor WWOX to Induce Apoptosis in Prostate Cancer Cells

Qunying Hong, Chun‐I Sze, Sing-Ru Lin, +8

PLoS ONE

17β-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo

Nan‐Shan Chang, Lori Schultz, Li‐Jin Hsu, +3

Oncogene

Tumor BiologyBreast OncologyHormonal Receptor17β-Estradiol UpregulatesPremetastatic State +11

Transforming Growth Factor β1 Signaling via Interaction with Cell Surface Hyal-2 and Recruitment of WWOX/WOX1

Li‐Jin Hsu, Lori Schultz, Qunying Hong, +10

Journal of Biological Chemistry

Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses

Nan‐Shan Chang, Joan Doherty, Amy Ensign, +5

Biochemical Pharmacology

Reductive StressWox1 ActivationSignal TransductionSignaling PathwayApoptosis +7

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease

M.H. Lee, S-R Lin, J-Y Chang, +9

Cell Death and Disease

Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed

Li‐Jin Hsu, Qunying Hong, Shur-Tzu Chen, +10

Oncotarget

Cell DeathPathologyCancer BiologyCellular PhysiologyTumor Biology +22

Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response

Qunying Hong, Li‐Jin Hsu, Lori Schultz, +3

BMC Molecular Biology