New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease

Gerald Kleymann, Rüdiger Fischer, Ulrich A. K. Betz, +20

Nature Medicine

Drug CandidatesMedicineAntiviral Drug DevelopmentAntiviral TherapyTherapeutic Efficacy +8

Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance

Frank Boess, Martin Hendrix, F. Josef van der Staay, +7

Neuropharmacology

Phosphodiesterase 2Synaptic PlasticityNeurophysiologySynaptic TransmissionPhysiology +9

Design and Synthesis of New Aminoglycoside Antibiotics Containing Neamine as an Optimal Core Structure:  Correlation of Antibiotic Activity with in Vitro Inhibition of Translation

William A. Greenberg, E. Scott Priestley, P.S. Sears, +5

Journal of the American Chemical Society

Peptide ScienceAntimicrobial ChemotherapyChemical BiologyA-site RnaPharmaceutical Chemistry +20

Direct Observation of Aminoglycoside−RNA Interactions by Surface Plasmon Resonance

Martin Hendrix, E. Scott Priestley, Gerald F. Joyce, +1

Journal of the American Chemical Society

Probing the Specificity of Aminoglycoside−Ribosomal RNA Interactions with Designed Synthetic Analogs

Phil B. Alper, Martin Hendrix, P.S. Sears, +1

Journal of the American Chemical Society

Molecular BiologyEscherichia ColiPeptide ScienceAntimicrobial ChemotherapyChemical Biology +16

Time-dependent involvement of cAMP and cGMP in consolidation of object memory: Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors

Kris Rutten, Jos Prickaerts, Martin Hendrix, +2

European Journal of Pharmacology

Object MemoryMemory SystemMedicineMemory LossMemory +8

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents

F. Josef van der Staay, Kris Rutten, Lars Bärfacker, +11

Neuropharmacology

Alzheimer's DiseaseBrain FunctionMedicinePharmacologyNeuropharmacology +4

Specificity of aminoglycoside antibiotics for the A-site of the decoding region of ribosomal RNA

Chi‐Huey Wong, Martin Hendrix, E. Scott Priestley, +1

Chemistry & Biology

BiochemistryRibosomal RnaNatural SciencesRna Structure PredictionMolecular Biology +9

Characterization of the First Potent and Selective PDE9 Inhibitor Using a cGMP Reporter Cell Line

Frank Wunder, Adrian Tersteegen, Annegret Rebmann, +3

Molecular Pharmacology

The Novel α7 Nicotinic Acetylcholine Receptor Agonist N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide Improves Working and Recognition Memory in Rodents

Frank Boess, Jean De Vry, Christina Erb, +9

Journal of Pharmacology and Experimental Therapeutics