Systematic investigation of cytokine signaling activity at the tissue and single-cell levels

Peng Jiang, Yu Zhang, Beibei Ru, +9

Nature Methods

InflammationSingle-cell LevelsCytokineSignal TransductionAutoimmune Disease +11

Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behçet's disease: an open-label pilot study

Ahmet Gül, İlknur Tuğal-Tutkun, Charles A. Dinarello, +5

Annals of the Rheumatic Diseases

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

Vinay Bhaskar, Johnny Yin, Amer M. Mirza, +6

Atherosclerosis

InflammationVascular DiseaseCardiovascular DiseaseIl-1 BetaImmunology +10

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Eswari Dodagatta-Marri, Dominique S. Meyer, Melissa Quino Reeves, +21

Journal for ImmunoTherapy of Cancer

A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB

Amer M. Mirza, S. L. Liu, Edward Frizell, +7

American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver FibrosisImmunologyPathologyCell DeathFatty Liver Disease +23

Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT

Amer M. Mirza, Stephan Gysin, Nisar P. Malek, +3

Molecular and Cellular Biology

Induction of Tubulogenesis in Telomerase-Immortalized Human Microvascular Endothelial Cells by Glioblastoma Cells

Eleni Venetsanakos, Amer M. Mirza, Christie Fanton, +3

Experimental Cell Research

AngiogenesisGliomaBiological MicroenvironmentsVascular BiologyBiomedical Engineering +7

Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy

Masaki Terabe, Faith C. Robertson, Katharine Clark, +6

OncoImmunology

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

John G. Shelton, Linda S. Steelman, John Tayu Lee, +8

Oncogene

CytokineSignal TransductionSignaling PathwayCell RegulationHematopoietic Cells +8

Insulin-Like Growth Factor Binding Protein-1 Is Elevated in Patients With Polycythemia Vera and Stimulates Erythroid Burst Formation In Vitro

Amer M. Mirza, Shereen Ezzat, Arthur A. Axelrad

Blood