Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.9K citations · Full text

Life Sciences, Cell Biology, Immunology +12

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

Herbert Tilg, Elizabeth Trehu, MB Atkins et al. · Blood · 1994 · 794 citations · Full text

Life Sciences, Immunology, Pharmacology +14

Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

Hirokazu Kirii, Tamikazu Niwa, Yasuhiro Yamada et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2003 · 739 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

Jan A. Ehses, Grégory Lacraz, M.H. Giroix et al. · Proceedings of the National Academy of Sciences · 2009 · 346 citations

Veterinary Medicine, Endocrinology, Physiology +17

Lack of Interleukin-1 Receptor Antagonist Modulates Plaque Composition in Apolipoprotein E–Deficient Mice

Kikuo Isoda, Shojiro Sawada, Norio Ishigami et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2004 · 162 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +15