Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Wenyu Yu, Emma J. Chory, Amy K. Wernimont, +23

Nature Communications

BiochemistryNatural SciencesBiocatalysisCatalytic Site RemodellingEnzyme Catalysis +6

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

Sina Haftchenary, H. Artee Luchman, Andriana O. Jouk, +13

ACS Medicinal Chemistry Letters

High-grade GliomasTreating GlioblastomaCancer BiologyGliomaTumor Biology +19

A High Through-put Platform for Recombinant Antibodies to Folded Proteins

Michael Hornsby, Marcin Paduch, Shane Miersch, +27

Molecular & Cellular Proteomics

Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids

James McNulty, Jerald J. Nair, Carles Codina, +4

Phytochemistry

MedicineApoptosisSelective Apoptosis-inducing ActivityCell DeathPhytopharmacology +3

Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells

Natasha Kekre, Carly Griffin, James McNulty, +1

Cancer Chemotherapy and Pharmacology

Tumor BiologyLymphoid NeoplasiaEarly ActivationHuman Lymphoma CellsMedicine +9

Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells

James McNulty, Jerald J. Nair, Jaume Bastida, +2

Phytochemistry

BiochemistryMedicineApoptosisLycorine PharmacophoreCell Death +8

An Allosteric Inhibitor of Protein Arginine Methyltransferase 3

Alena Siarheyeva, Guillermo Senisterra, Abdellah Allali‐Hassani, +22

Structure

BiochemistryProtein BiosynthesisDrug DiscoveryAllosteric InhibitorMedicine +1

Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract

Pamela Ovadje, Sudipa June Chatterjee, Carly Griffin, +3

Journal of Ethnopharmacology

MedicineApoptosisImmunologyCell DeathDandelion Root Extract +7

Pancratistatin Selectively Targets Cancer Cell Mitochondria and Reduces Growth of Human Colon Tumor Xenografts

Carly Griffin, Aditya Karnik, James McNulty, +1

Molecular Cancer Therapeutics

Chemoenzymatic Synthesis of Amaryllidaceae Constituents and Biological Evaluation of their C-1 Analogues. The Next Generation Synthesis of 7-Deoxypancratistatin and <i>trans</i>-Dihydrolycoricidine

Jonathan Collins, Uwe Rinner, Michael T. Moser, +7

The Journal of Organic Chemistry

Amaryllidaceae ConstituentsMedicinal ChemistryBiosynthesisNatural Product SynthesisDerivative (Chemistry) +13