Alex D. Lewis

Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes.

Shiuan Chen, R.J. Knox, Alex D. Lewis et al. · Molecular Pharmacology · 1995 · 57 citations

Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species56Abbreviations: EORTC, European Organisation for the Research and Treatment of Cancer; DMPO, 5,5-dimethyl-1-pyrroline-1-oxide; and AN and AH, hyperfine-splitting constants for nitrogen and hydrogen, respectively.

Susan M. Bailey, Alex D. Lewis, Laurence H. Patterson et al. · Biochemical Pharmacology · 2001 · 37 citations

Reductive Stress, Biochemistry, Medicine +9

Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites

Susan M. Bailey, Alex D. Lewis, Richard J. Knox et al. · Biochemical Pharmacology · 1998 · 32 citations

Medicinal Chemistry, Pharmaceutical Science, Natural Product Synthesis +11

Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin‐sensitive (A2780) and ‐resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis

I.M. Huxham, Andrew L. Barlow, Alex D. Lewis et al. · International Journal of Cancer · 1994 · 12 citations

Dose-Response Curve for Chromosome Translocations Induced by Low Dose Rate 137Cs Gamma Rays

J. N. Lucas, Francesca Hill, C.E. Burk et al. · Radiation Protection Dosimetry · 1997 · 12 citations