Synthesis and hypotensive activity of N-alkyl-N''-cyano-N'-pyridylguanidines

Hans Petersen, C. Nielsen, E. Arrigoni‐Martelli

Journal of Medicinal Chemistry

N″-cyano-N-4-pyridyl-N′-1,2,2-trimethylpropylguanidine, monohydrate (P 1134): A new, potent vasodilator

E. Arrigoni‐Martelli, C. Nielsen, Uffe Bang Olsen, +1

Cellular and Molecular Life Sciences

Medicinal ChemistryPotent VasodilatorOrganic ChemistryPharmacologyPharmaceutical Chemistry

<i>N</i>-Substituted Adenosines as Novel Neuroprotective A₁ Agonists with Diminished Hypotensive Effects

Lars J. S. Knutsen, Jesper Lau, Hans Petersen, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryReference Adenosine AgonistsBiochemistryNovel Adenosine Derivatives +13

Synthesis of Novel GABA Uptake Inhibitors. 3. Diaryloxime and Diarylvinyl Ether Derivatives of Nipecotic Acid and Guvacine as Anticonvulsant Agents

Lars J. S. Knutsen, Knud Erik Andersen, Jesper Lau, +10

Journal of Medicinal Chemistry

Nipecotic AcidPharmacotherapyGaba Uptake InhibitorPharmaceutical ChemistryMolecular Pharmacology +14

Synthesis of Novel γ-Aminobutyric Acid (GABA) Uptake Inhibitors. 5. Preparation and Structure−Activity Studies of Tricyclic Analogues of Known GABA Uptake Inhibitors

Knud Erik Andersen, Jan L. Sørensen, Jesper Lau, +5

Journal of Medicinal Chemistry

Novel γ-Aminobutyric AcidTricyclic AnaloguesPharmaceutical ScienceNipecotic AcidPharmacotherapy +15

Synthesis of Novel GABA Uptake Inhibitors. 4. Bioisosteric Transformation and Successive Optimization of Known GABA Uptake Inhibitors Leading to a Series of Potent Anticonvulsant Drug Candidates

Knud Erik Andersen, Jan L. Sørensen, Per Olaf Huusfeldt, +6

Journal of Medicinal Chemistry

Medicinal ChemistrySuccessive OptimizationBiochemistryMedicineBioisosteric Transformation +12

Synthesis of novel GABA uptake inhibitors. part 6 : Preparation and evaluation of N-Ω asymmetrically substituted nipecotic acid derivatives

Knud Erik Andersen, Jesper Lau, Behrend F. Lundt, +4

Bioorganic & Medicinal Chemistry

Metabolism of the new antihypertensive agent pinacidil in rat, dog and man

E. Eilertsen, M. P. Magnussen, Hans Petersen, +3

Xenobiotica

HypertensionFaecal ExcretionAntihypertensive Agent PinacidilGastrointestinal PharmacologyPharmacotherapy +19

The synthesis of novel GABA uptake inhibitors. Part 2. Synthesis of 5-hydroxytiagabine, a human metabolite of the GABA reuptake inhibitor tiagabine

Knud Erik Andersen, Mikael Begtrup, Mukund S. Chorghade, +6

Tetrahedron

Medicinal ChemistryPharmaceutical ChemistryBiochemistryMedicineNatural Sciences +8

Comparative Effects of Tetragastrin and Histamine on Acid and Intrinsic Factor Secretion in Man

K.H. Køster, P. Rødbro, Hans Petersen

Scandinavian Journal of Gastroenterology

Gastrointestinal PharmacologyGastroenterologyPharmacotherapyIntrinsic FactorhistamineExperimental Pharmacology +17